Tirzepatide

Kodi Tirzepatide ndi chiyani?

Tirzepatide ndi mankhwala atsopano omwe amavomerezedwa ndi FDA pochiza matenda amtundu wa 2 mellitus. Chifukwa cha mphamvu zake zochepetsera thupi, gulani tirzepatide kuti igwiritsidwe ntchito pochiza kunenepa kwambiri.

Imagwira ntchito ngati agonist wapawiri wa GLP-1 ndi GIP agonist kuti muwonjezere zopindulitsa zomwe zimawonedwa ndi mankhwala a GLP-1 monga semaglutide.Pakali pano akugwiritsidwa ntchito ngati mankhwala amtundu wachiwiri wa matenda a shuga, ofanana ndi mankhwala a GLP-1, ndipo amaperekedwa ngati jekeseni ya subcutaneous kamodzi pa sabata. The FDA inavomereza peptide Tirzepatide mu Meyi 2022.

Kodi Tirzepatide Imagwira Ntchito Motani?

Tirzepatide ndi peptide yopanga; ndi dual gastric inhibitory polypeptide (GIP) ndi glucagon-ngati peptide 1 (GLP-1) receptor agonist. Imapangidwa ndi 39 amino acid ndipo ndi analogi ya m'mimba inhibitory polypeptide. M'malo mwake, imathandizira kutulutsidwa kwa insulin kuchokera ku kapamba ndipo imayambitsa kuchepa kwa hyperglycemia. Kuphatikiza apo, Tirzepatide imawonjezeranso milingo ya adiponectin. Kuthekera kwake kwapawiri kumabweretsa kuchepa kwakukulu kwa hyperglycemia kuposa othandizira a GLP-1 okha ndikuchepetsa chidwi cha wosuta.

Ubwino wa Tirzepatide

Tirzepatide ndi cholandilira insulinotropic polypeptide (GIP) chodalira glucose komanso glucagon-like peptide-1 (GLP-1) receptor agonist, yomwe imavomerezedwa ndi FDA pochiza matenda amtundu wa 2 mellitus. Ndikofunikira kudziwa kuti tirzepatide ndiyosavomerezeka pochiza matenda a shuga 1 ndipo sanaphunzirepo kwa odwala omwe ali ndi kapamba. Tirzepatide ndi GIP receptor ndi GLP-1 receptor agonist, zomwe zimapangitsa kuti glycemic ikhale yabwino. kuwongolera mu mtundu wa 2 shuga ndi kulemera kwakukulu kuchepetsa.

Zotsatira za Tirzepatide

Odwala omwe ali ndi kunenepa kwambiri komanso mtundu wa 2 shuga (T2D) kapena onenepa kwambiri ndi T2D adataya pafupifupi mapaundi 34.4 (15.7%) a kulemera kwa thupi ndi 10 mg ndi 15 mg ya tirzepatide (Mounjaro; Eli Lilly ndi Company), malinga ndi zomwe apeza kuchokera ku SURMOUNT -2 padziko lonse lapansi gawo 3 kuyesa. Makamaka, tirzepatide pa 10 mg inachepetsa kulemera kwa thupi ndi 5% kapena kuposerapo mu 79.2% ya odwala ndikuchepetsa kulemera kwa thupi ndi 12.8%, pamene mlingo wa 15 mg umachepetsa kulemera kwa 82.7% ya odwala ndikuchepetsa thupi ndi 14.7%.

Tirzepatide Amagwiritsidwa Ntchito Pochepetsa Kuwonda

Tirzepatide ndi jekeseni kamodzi pa sabata kuti muchepetse shuga wamagazi. Kuyambira 2022 yawonetsa zotsatira zochepetsera thupi ndipo ili pachiwonetsero chofulumira kuti iwunikenso pakuchiza kunenepa kwambiri. Pa avareji, odwala anaona chodabwitsa kuwonda kupitirira 20% ya kulemera kwawo koyamba.

Tirzepatide ndi Chithunzi cha BPC157 thandizani kuwonda pochepetsa kudya komanso kuchepetsa momwe chakudya chimayendera m'matumbo anu. Izi zingakuthandizeni kuti mukhale okhuta nthawi yayitali komanso kuchepetsa kuchuluka kwa chakudya chomwe mumadya. Kafukufuku akuwonetsa kuti izi zitha kuchitika muubongo.

Momwe ikugwirira ntchito:

●Chepetsani kuchuluka kwa zakudya zomwe zimadyedwa.

●Imaletsa chiwindi kupanga ndi kutulutsa shuga wambiri.

●Zimachedwetsa kuti chakudya chimachoka msanga m’mimba.

●Thupi limatulutsa insulini shuga ikakwera.

●Thupi limachotsa shuga wambiri m’magazi.

Kodi pali kusiyana kotani pakati pa Tirzepatide ndi Semaglutide?

Tirzepatide imagwira ntchito pa ZONSE GIP ndi GLP-1 zolandilira, pomwe Semaglutide imangogwira pa GLP-1 receptors. Onse mankhwala ndi othandiza kuchepetsa thupi. Tirzepatide ndi yapawiri-acting GIP (glucose-dependent insulinotropic polypeptide) ndi GLP-1.glucagon-ngati peptide-1) receptor agonist. Onsewa ali m'gulu la mankhwala omwe amadziwika kuti incretin mimetics koma amasiyana.

Kusintha kwa moyo komanso kuletsa ma calorie kumabweretsa zotsatira zabwino kwambiri. Ubwino wa kuwonda ndi kuwongolera kophatikizana kwa kunenepa kwambiri monga matenda a shuga, kuthamanga kwa magazi, lipids osakhazikika m'magazi, ndi matenda amtima omwe amatha kuwonedwa ndi kuchepa pang'ono kwa 5%.

Zotsatira za Tirzepatide

Chofala kwambiri zotsatira zoyipazi Mankhwala a Tirzepatide amaphatikizapo nseru, kutsegula m'mimba, kuchepa kwa njala, kusanza, kudzimbidwa, kusanza, ndi kupweteka kwa m'mimba (m'mimba). Izi sizomwe zingatheke zotsatira zoyipazi mankhwala a Tirzepatide. Lankhulani ndi wothandizira zaumoyo wanu za chilichonse zotsatira zoyipazi mukhoza kukumana nazo.

Kodi Mungagule Kuti Tirzepatide?

AASraw ndi malo abwino kwambiri ogulira Tirzepatide yogulitsa. Zogulitsa zathu zonse zimabwera ndi Sitifiketi Yowunikira yodziyimira payokha, yoperekedwa ndi gulu lachitatu kuti zizindikirike, chiyero, komanso kukhazikika. Ndipo tili ndi Tirzepatide yochulukira yogulitsa pamsika!

AASraw ndi wothandizira wa Tirzepatide ndi Tirzepatide wopanga omwe ali ndi labu yodziimira okha ndi fakitale yaikulu monga chithandizo, onse. Kupanga zidzachitika motsogozedwa ndi CGMP komanso njira yoyendetsera bwino. Njira yoperekera tirzepatide ndiyokhazikika, ndipo maoda onse ogulitsa ndi ogulitsa ndi ovomerezeka. Ngati mukufuna kugula Tirzepatide pa intaneti, talandilani kukaona tsamba lathu (aasraw.com).

Tirzepatide Testing Report-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Kodi mungagule bwanji Tirzepatide kuchokera ku AASraw?

❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) adzakulumikizani pakadutsa maola 12.

❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.

❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).

❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.

❺Katundu wolandilidwa ndi kupereka ndemanga.

Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Qi Liu
Dipatimenti ya Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China
2. Sidar Copur
Dipatimenti ya Zamankhwala, Koc University School of Medicine, Istanbul 34010, Turkey
3. Rouchan Ali
Dipatimenti ya Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, Moga 142001, Punjab, India
4. V. Thieu
Eli Lilly, Medical Affairs, Indianapolis, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Zothandizira

[1] Lilly :Zotsatira za Gawo 3 la Tirzepatide Zimasonyeza A1C Yapamwamba Komanso Kuchepetsa Kulemera kwa Thupi Mumtundu Wachiwiri wa Matenda a Shuga”.Business Insider.RTTNews.2 October 19.Zosungidwa kuyambira pachiyambi pa 2021 October 28.Zabwezedwanso 2021 October 28.

[2] Tirzepatide inachepetsa kwambiri A1C ndi kulemera kwa thupi mwa anthu omwe ali ndi matenda a shuga a mtundu wa 2 m'mayesero awiri amtundu wa 3 kuchokera ku pulogalamu ya Lilly's SURPASS” (Press release).Eli Lilly and Company.17 February 2021.Yosungidwa kuchokera pachiyambi pa 28 October 2021.Yabwezedwanso 28 October 2021 - kudzera pa PR Newswire.

[3] Kellaher,Colin (28 Epulo 2022)."Eli Lilly's Tirzepatide Yakumana ndi Mapeto Aakulu mu Gawo 3 Phunziro la Kunenepa Kwambiri".MarketWatch.Dow Jones Newswires.Yosungidwa kuchokera koyambirira pa 29 Epulo 2022.Idabwezedwanso pa 29 Epulo 2022.

[4] Willard FS,Douros JD,Gabe MB,Showalter AD,Wainscott DB,Suter TM,et al.(September 2020).”Tirzepatide ndi wosagwirizana komanso wokondera wapawiri GIP ndi GLP-1 receptor agonist”.JCI Insight.5 (17) .doi:10.1172/jci.insight.140532.PMC 7526454.PMID 32730231.

[5] Frederick MO,Boyse RA,Braden TM,Calvin JR,Campbell BM,Changi SM,et al.(2021)."Kilogram-Scale GMP Kupanga Tirzepatide Pogwiritsa Ntchito Hybrid SPPS/LPPS Approach with Continuous Manufacturing”.Organic Process Research & Development .25 ( 7): 1628-1636 .

[6] Frías JP,Davies MJ,Rosenstock J,Pérez Manghi FC,Fernández Landó L,Bergman BK,et al.(August 2021)."Tirzepatide versus Semaglutide Kamodzi pamlungu kwa Odwala omwe ali ndi matenda a shuga amtundu wa 2".The New England Journal of Medicine.385 (6): 503–515.doi:10.1056/NEJMoa2107519.

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