Mafotokozedwe Akatundu
Kodi Tirzepatide ndi chiyani?
Tirzepatide ndi mankhwala atsopano omwe avomerezedwa ndi FDA kuti azichiza matenda amtundu wa 2 mellitus.
Imagwira ntchito ngati agonist wapawiri wa GLP-1 ndi GIP agonist kuti muwonjezere zopindulitsa zomwe zimawonedwa ndi mankhwala a GLP-1 monga semaglutide.Pakali pano akugwiritsidwa ntchito ngati mankhwala amtundu wachiwiri wa matenda a shuga, ofanana ndi mankhwala a GLP-1, ndipo amaperekedwa ngati jekeseni kamodzi pa sabata. A FDA adavomereza peptide Tirzepatide mu May 2022.
Kodi Tirzepatide Imagwira Ntchito Motani?
Tirzepatide ndi peptide yopanga; ndi dual gastric inhibitory polypeptide (GIP) ndi glucagon-like peptide 1 (GLP-1) receptor agonist. Imapangidwa ndi 39 amino acid ndipo ndi analogi wa gastric inhibitory polypeptide. Kuonjezera apo, Tirzepatide imawonjezeranso kuchuluka kwa adiponectin.Kutha kwake kwapawiri kwa agonism kumabweretsa kuchepa kwakukulu kwa hyperglycemia kuposa GLP-1 agonist agents okha ndikuchepetsa chidwi cha wosuta.
Ubwino wa Tirzepatide
Tirzepatide ndi cholandilira insulinotropic polypeptide (GIP) chodalira glucose komanso glucagon-ngati peptide-1 (GLP-1) receptor agonist, yomwe ndi yovomerezeka ndi FDA pochiza matenda amtundu wa 2 mellitus. kuchiza matenda a shuga amtundu wa 1 ndipo sanaphunzirepo kwa odwala omwe ali ndi kapamba.Tirzepatide ndi GIP receptor ndi GLP-1 receptor agonist, zomwe zimapangitsa kuti glycemic control yamtundu wa 2 ikhale yabwino komanso kuchepetsa kwambiri kulemera.
Zotsatira za Tirzepatide
Odwala omwe ali ndi kunenepa kwambiri komanso mtundu wa 2 shuga (T2D) kapena onenepa kwambiri ndi T2D adataya pafupifupi mapaundi 34.4 (15.7%) a thupi ndi 10 mg ndi 15 mg ya tirzepatide (Mounjaro; Eli Lilly ndi Company), malinga ndi zomwe zapeza kuchokera ku SURMOUNT Mayesero a 2 padziko lonse lapansi a 3. Mwachindunji, tirzepatide pa 10 mg inachepetsa kulemera kwa thupi ndi 5% kapena kuposerapo mu 79.2% ya odwala ndi kuchepetsa kulemera kwa thupi ndi 12.8%, pamene mlingo wa 15 mg umachepetsa kulemera kwa 82.7% ya odwala ndi kuchepa kwapakati kulemera kwa thupi ndi 14.7%.
Tirzepatide Amagwiritsidwa Ntchito Pochepetsa Kuwonda
Tirzepatide, ndi jekeseni kamodzi pamlungu kuti achepetse shuga. kupitirira 2022% ya kulemera kwawo koyamba.
Tirzepatide ndi Chithunzi cha BPC157 kumathandiza kuchepetsa thupi mwa kuchepetsa kudya komanso kuchepetsa momwe chakudya chimayendera m'mimba mwako. Izi zingakuthandizeni kuti mukhale okhuta komanso kuchepetsa kuchuluka kwa zakudya zomwe mumadya. Kafukufuku amasonyeza kuti izi zikhoza kuchitika mu ubongo.
Momwe ikugwirira ntchito:
●Chepetsani kuchuluka kwa zakudya zomwe zimadyedwa.
●Imaletsa chiwindi kupanga ndi kutulutsa shuga wambiri.
●Zimachedwetsa kuti chakudya chimachoka msanga m’mimba.
●Thupi limatulutsa insulini shuga ikakwera.
●Thupi limachotsa shuga wambiri m’magazi.
Kodi pali kusiyana kotani pakati pa Tirzepatide ndi Semaglutide?
Tirzepatide imagwira ntchito pa ZONSE GIP ndi GLP-1 zolandilira, pomwe Semaglutide imangogwira pa GLP-1 receptors. Mankhwala onsewa ndi othandiza kuchepetsa thupi. -monga peptide-1) receptor agonist. Onsewa ali m'gulu la mankhwala omwe amadziwika kuti incretin mimetics koma ali ndi zosiyana.
Kusintha kwa moyo ndi kuchepetsa calorie kudzatsogolera ku zotsatira zabwino zonse. Phindu la kuwonda ndilobwinoko comorbidities za kunenepa kwambiri monga shuga, kuthamanga kwa magazi, lipids yamagazi osadziwika bwino ndi matenda a mtima omwe amatha kuwonedwa ndi kuchepa kwa 5%.
Zotsatira za Tirzepatide
Zotsatira zofala kwambiri za Tirzepatide ndi monga nseru, kutsegula m'mimba, kuchepa kwa njala, kusanza, kudzimbidwa, kusagawika m'mimba, kupweteka kwa m'mimba (m'mimba). zochitika.
Kodi Mungagule Kuti Tirzepatide?
AASraw ndi malo abwino kwambiri ogulira Tirzepatide wholesale.Zogulitsa zathu zonse zimabwera ndi Certificate yodziyimira payokha, yoperekedwa ndi gulu lachitatu kuti tidziwe, chiyero, ndi kuika maganizo.Ndipo tili ndi Tirzepatide yochuluka yogulitsa katundu!
AASraw ndi Tirzepatide supplier ndi Tirzepatide wopanga omwe ali ndi labu yodziyimira pawokha ndi fakitale yayikulu monga chithandizo, zopanga zonse zizichitika motsogozedwa ndi CGMP ndi trackable control system. kugula Tirzepatide pa intaneti, talandilani kukaona tsamba lathu (aasraw.com).
Tirzepatide Testing Report-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Kodi mungagule bwanji Tirzepatide kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Zothandizira
[1] Lilly :Zotsatira za Gawo 3 la Tirzepatide Zimasonyeza A1C Yapamwamba Komanso Kuchepetsa Kulemera kwa Thupi Mumtundu Wachiwiri wa Matenda a Shuga”.Business Insider.RTTNews.2 October 19.Zosungidwa kuyambira pachiyambi pa 2021 October 28.Zabwezedwanso 2021 October 28.
[2] Tirzepatide inachepetsa kwambiri A1C ndi kulemera kwa thupi mwa anthu omwe ali ndi matenda a shuga a mtundu wa 2 m'mayesero awiri amtundu wa 3 kuchokera ku pulogalamu ya Lilly's SURPASS” (Press release).Eli Lilly and Company.17 February 2021.Yosungidwa kuchokera pachiyambi pa 28 October 2021.Yabwezedwanso 28 October 2021 - kudzera pa PR Newswire.
[3] Kellaher,Colin (28 Epulo 2022)."Eli Lilly's Tirzepatide Yakumana ndi Mapeto Aakulu mu Gawo 3 Phunziro la Kunenepa Kwambiri".MarketWatch.Dow Jones Newswires.Yosungidwa kuchokera koyambirira pa 29 Epulo 2022.Idabwezedwanso pa 29 Epulo 2022.
[4] Willard FS,Douros JD,Gabe MB,Showalter AD,Wainscott DB,Suter TM,et al.(September 2020).”Tirzepatide ndi wosagwirizana komanso wokondera wapawiri GIP ndi GLP-1 receptor agonist”.JCI Insight.5 (17) .doi:10.1172/jci.insight.140532.PMC 7526454.PMID 32730231.
[5] Frederick MO,Boyse RA,Braden TM,Calvin JR,Campbell BM,Changi SM,et al.(2021)."Kilogram-Scale GMP Kupanga Tirzepatide Pogwiritsa Ntchito Hybrid SPPS/LPPS Approach with Continuous Manufacturing”.Organic Process Research & Development .25 ( 7): 1628-1636 .
[6] Frías JP,Davies MJ,Rosenstock J,Pérez Manghi FC,Fernández Landó L,Bergman BK,et al.(August 2021)."Tirzepatide versus Semaglutide Kamodzi pamlungu kwa Odwala omwe ali ndi matenda a shuga amtundu wa 2".The New England Journal of Medicine.385 (6): 503–515.doi:10.1056/NEJMoa2107519.
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