Mafuta a urolithin oyera amagulitsa kwambiri
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Urolithin Wobwerera Kumbuyo

Phindu la khangaza lachititsa ofufuza kuti afufuze momwe zipatso zofiira izi zingatithandizire kukhala athanzi. Pakufufuza kwaposachedwa, ofufuza aku Switzerland apeza molekyulu yatsopano yomwe imadza chifukwa chotsegula mankhwala awiri omwe amapezeka m'makangaza: punicalagins ndi ellagitannins. Molekyu yapaderayi, yotchedwa urolithin A, imathandizira kukonzanso mitochondria, nyumba zathu zamagetsi zamagetsi. Urolithin A imatsegula chitseko cha chithandizo chamankhwala chatsopano chothana ndi zovuta zokhudzana ndi ukalamba, kuphatikiza kufooka, komwe kumayambitsa chiwopsezo cha anthu olumala, ogonekedwa mchipatala, komanso omwalira.

Urolithin Mwachidule

Urolithin A ndi mankhwala a metabolite, omwe ali m'gulu la mankhwala omwe amadziwika kuti benzo-coumarins. Ndizopangidwa kumapeto kwa chakudya chomwe chimakhala ndi ellagitannins (polyphenols) ndipo chimagwiritsidwa ntchito ndimatenda amthupi. Mwanjira ina, Urolithin A amapangidwa pamene munthu ameza chakudya chomwe chili ndi ellagitannins.

Urolithin A sichimachitika mwachilengedwe pamapeto pake. Zakudya za Ellagitannin, monga mitundu ina ya zipatso ndi makangaza, ziyenera kupukusidwa ndi mabakiteriya am'mimba kuti apange. Kuti kampaniyo igwiritse ntchito moyenera, imayenera kupangidwa mu labu, kapena mwanjira ina, Urolithin A iyenera kupangidwa kuti izitha kugwiritsidwa ntchito.

Kafukufuku wasayansi wasonyeza kuti Urolithin A ali ndi zida zotsutsana ndi ukalamba. Amati amathandizira kupangika kwa minofu, amakhala ndi zinthu zotsutsana ndi zotupa, ndipo adawonetsanso kuthekera kokulitsa thanzi laukalamba kwa okalamba.

Urolithin Njira Yogwirira Ntchito

Kodi Urolithin A amagwira ntchito bwanji? Ellagic acids ndi Ellagitannins ndi omwe amatsogolera Urolithin A.

Ellagitannins amatulutsidwa kuchokera m'matumbo kuti atulutse Ellagic acid, ndipo izi zimakonzedwa kuchokera m'matumbo microflora kupita ku urolithins kudzera mukuwonjezeka kochulukirapo mu 1 mwa ma lactones awiri motsatizana kuchotsa magulu a hydroxyl. Mukamadya m'matumbo, Urolithin A ufa umalowa mu dongosolo la m'matumbo.

Mitophagy, malinga ndi tanthauzo la Wikipedia, ndiye kuwonongeka kwa mitochondria yanu mwa kudzipangira. Nthawi zambiri zimapezeka ndi mitochondria yolakwika pambuyo povulala kapena kupsinjika. Komabe, tikamakalamba, ntchito ya Mitophagy imayamba kuchepa. Mwamwayi, Urolithin A imavomerezedwa kuti ipangitse mitophagy m'njira yosungidwa pamitundu yosiyanasiyana.

Ubwino / Zotsatira za Urolithin A.

❶ Urolithin A Athandiza Kuthetsa Khansa

Ngakhale chithandizo chamankhwala opondereza komanso chemotherapy, pafupifupi 50% ya anthu omwe ali ndi khansa yoyipa amayamba zotupa zobwerezabwereza. Izi zikhoza kukhala chifukwa cha kupulumuka kwa maselo oopsa a khansa ya m'matumbo omwe amatsutsana ndi mankhwala ochiritsira komanso "mbewu" za khansa.
Pazosangalatsa, ofufuza adatulutsa maselo am'magazi a khansa m'matumbo kuchokera kwa wodwala yemwe ali ndi khansa yamtundu wamtundu uliwonse osakaniza okhala ndi 85% urolithin A kapena 30% urolithin A. Zotsatirazo zinali zosangalatsa. Kusakanikirana kwakukulu kwa urolithin Kusakanikirana kwamtunduwu kunali kothandiza kwambiri poletsa kuchuluka ndi kukula kwa maselo am'magazi a khansa ya m'matumbo ndikuletsa ntchito ya aldehyde dehydrogenase, chodziwitsa chemoresistance.
Njira yothandizirayi ndiyosangalatsa chifukwa njira zamankhwala zolimbana ndi khansa sizitha kupha kapena kuletsa kuchuluka kwa maselo am'mimba a khansa. Zotsatira zatsopanozi zikugwirizana ndi lingaliro loti njira ya michere ikhoza kukhala yothandiza ngati njira ina kapena njira yodzitetezera yolimbana ndi maselo owopsawa.

❷ Urolithin A - Zotsatira za Neuroprotective

Kulumikizana pakati pa makangaza ndi zotsatira zake zoteteza ku matenda a Alzheimer's kwakhazikitsidwa bwino pamaphunziro a zinyama.8 Komabe, zomwe zimayambitsa bioactive pankhaniyi sizimadziwika mpaka pano.
Matenda a Alzheimer akuyembekezeka kukhudza anthu opitilira 115 miliyoni padziko lonse pofika chaka cha 2050. Gulu la ofufuza lidayang'ana kafukufuku wakale wazinyama yemwe adanenapo zakusagwirizana ndi Alzheimer's zotsatira za makangaza.
Gululi linayesa kuthekera kwa zigawozi kudutsa malire a magazi ndi ubongo ndipo anapeza kuti mtundu wa methylated wa urolithin A (mUA), wochokera ku khangaza, pamodzi ndi ma urolithin ena amatha kutero.
Ndipo, ngakhale kuti pakufunika kafukufuku wambiri, olembawo adatsimikiza kuti ma urolithin ndi omwe amathandizira pazomwe zimayambitsa matenda a Alzheimer's omwe amateteza ku neurotoxicity ndi b-amyloid fibrillation. Zotsatirazi zikulonjeza, ndikuwonetsa kufunikira kofufuza njira zina zachilengedwe zopewera zakudya zopewera kapena kuchepetsa kukula kwa matenda a Alzheimer's.
Zotsatira ndi zomwe zapezeka m'maphunziro osiyanasiyanawa zimathandiziranso kufunikira kwa mankhwala a polyphenol metabolite monga urolithin A ochokera ku makangaza ndi gawo lawo polimbana ndi khansa ya m'matumbo ndi matenda opatsirana pogonana.
Kafukufuku adawonetsanso kuti Urolithin A imatha kulimbikitsa kulimba kwa minofu ndi kupirira kwa okalamba. Kafukufuku waposachedwa akuwonetsa kuti umboni woyambirira ukupereka zabwino zina za Urolithin A, kuphatikiza izi:

-Kuthana ndi zotupa
-Anticarcinogenic
-Zosakaniza
-Zosangalatsa
-Tizilombo toyambitsa matenda


Urolithin A imawonekeranso ngati chowonjezera pazopangira mapuloteni kuti athandize kuchita masewera olimbitsa thupi, komanso kuchepetsa kunenepa kwambiri.

Urolithin A Zotsatira zoyipa

M'mayesero omwe atchulidwawa, palibe zovuta zomwe zidanenedwapo. Pakufufuza kwamaphunziro angapo am'mbuyomu komanso zamankhwala, zikuwoneka kuti pali umboni wothandizira chitetezo cha Urolithin A.

Palibe zotulukapo zowopsa zomwe zafotokozedwapo, ngakhale m'maphunziro omwe amakhudza kwambiri makoswe m'maphunziro amenewo.

Urolithin A yakhazikitsidwa kuti isinthe makampani olimbana ndi ukalamba. Maphunziro azachipatala akadali koyambirira koma mayesero ambiri amawulula zotsatira zabwino popanda zovuta zina. Kuyambira pazakudya mpaka zowonjezera, Urolithin A akuyenera kukhala chinthu chatsopano chatsopano chomwe aliyense ayenera kutenga.

Urolithin A Zakudya Zakudya

Monga tanenera, Urolithin A pamapeto pake samawoneka mwachilengedwe. Sidziwika kuti amapezeka m'malo aliwonse opangira chakudya. Komabe, choyambirira cha panganolo chitha kupezeka mu zipatso ndi mtedza wina. Zakudya zomwe zimakhala ndi ellagitannins monga makangaza, rasipiberi, strawberries, cloudberries, ndi walnuts ndi zitsanzo.

Ma ellagitannins a zipatso ndi mtedzawu amapangidwa ndi hydrolyzed m'matumbo kuti apange ellagic acid, yomwe imakonzedwa m'matumbo ndikupukutidwa ndi m'matumbo microflora ku Urolithin A.

Ndikofunika kudziwa kuti Urolithin A samachitika nthawi zonse akamamwa. Matumbo a anthu ena alibe microflora yosakanikirana bwino kuti asinthe ellagic acid kukhala Urolithin A. Izi zikutanthauza kuti si aliyense amene angatulutse Urolithin A m'matumbo awo ngati adya makangaza, mtedza, kapena zipatso. Zonse zimadalira m'matumbo mabakiteriya omwe amapezeka mthupi lanu.

Njira Yopangira Urolithin

Urolithin A amapangidwa kudzera pamankhwala opangira pogwiritsa ntchito imodzi mwanjira zomwe tafotokozazi. Zonsezi zimakhudza kuyanjana kwa Ullmann, kutsatiridwa ndi mankhwala a Lewis acid kuti apange urolithin A woyeretsedwa kwambiri.

Chomaliza chimatsukidwa ndi njira zochiritsira zosungunulira, zosefedwa, zotsukidwa, ndi zouma kuti zipeze urolithin A. Chogulitsidwacho pambuyo pake chimachepetsa kukula kwa tinthu.

Malinga ndi njira zokhazikitsidwa bwino, Urolithin A ufa amapangidwa mwaluso ndikuyeretsedwa m'njira zingapo zingapo mpaka 99%. Zipangizo ndi njira zopangira zomwe zimakhudzana ndi kaphatikizidwe ka urolithin A zimaphatikizapo 2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminium chloride, Toluene , DMSO, Methanol, Acetic Acid, ndi TBME (tert-butyl-methyl ether).

Kupanga Urolithin A VS Natural Urolithin A

Monga tafotokozera pamwambapa, Urolithin A ndi m'mimba mwa mabakiteriya a ellagitannins (ET) kapena ellagic acid (EA). Ngati mukufuna kupeza Urolithin A wambiri, muyenera kuyamba kudya zipatso zazikulu, kenako ndikuwadikirira kuti achoke ku ellagitannins ndi ellagic acid kupita ku Urolithin A. Njirayi ndi yayitali, ndipo ndi yoyera kwambiri, ndipo koposa zonse , zikhala zodula kwambiri kutero.

Sikuti aliyense ali ndi microflora yoyenera yomwe imatha kupanga metabolite. Kuphatikiza apo, njirayi siyingagwiritsidwe ntchito popanga misa mu malo opanga ovomerezeka a GMP.

Nkhani yabwino ndiyakuti, ngati chinthu chatsopano, Urolithin A pamapeto pake amapezeka ku 2019 kuchokera ku Cima Science. Tsopano itha kupangidwa mu labu ndi fakitale. Kupanga kwa urolithin A kumafanana mofanana ndi urolithin A. Kuthekera kopanga zinthu kumafika 3000 kgs kapena 2.5 matani / mwezi.

Urolithin A Chitetezo

Urolithin A imavomerezedwa ndi European Union ngati chakudya chatsopano.

US Food and Drug Administration (FDA) mu 2018 yapatsa urolithin A momwe GRAS imagwiritsidwira ntchito pazakudya zowonjezera. GRAS imatanthauza kuti Urolithin A nthawi zambiri imawoneka ngati yotetezeka ndi mulingo wa 500mg mpaka 1 gramu pakatumikira.

Urolithin A chitetezo chidafufuzidwa pamayeso angapo azachipatala komanso zamankhwala, zomwe zimalimbikitsa chitetezo chaumoyo pazogwiritsira ntchito. Kuchulukitsa kwamasiku 28 ndi maphunziro a masiku 90 a urolithin A mu makoswe sikunawonetsere kuwopsa kwa zoopsa zina mwa magawo omwe amayesedwa munjira iliyonse yomwe adayesedwa.

Zowonjezera mpaka masiku 90 ndi urolithin A sizinapangitse zizindikiritso zamitsempha yamaubongo kapena kubereka munthawi zowunika zowunika mobwerezabwereza monga kuwunika kwa ma spermatogenesis kapena ma oestrus, mayeso a ophthalmoscopic, kuwonetsetsa kwa batri, ndi magalimoto kuwunika.

Takulandirani Kuti Mugule Urolithin A / Urolithin A 8-Methyl Ether Bulk Powder kuchokera ku AASraw!

Kupezeka kwa urolithin A, komwe kumachokera ku ma punicalagins ndi ellagitannins omwe amapezeka m'makangaza, kumapereka mipata yatsopano yolimbana ndi kuchepa kwa ntchito ya mitochondrial komanso kufooka ndi kutayika kwa minofu.

Mwa kuthandiza maselo kuti adzikonzenso okha ndikuthandizira kugwira ntchito kwa minofu, makangaza ndi mankhwala ake aposachedwa kwambiri, urolithin A-atha kuchita bwino.

Kuphatikiza pa zomwe apezazi, pali umboni wotsimikizira za mphamvu zomwe urolithin A ali nazo motsutsana ndi matenda a Alzheimer ndi khansa, zomwe zimaperekanso chida china cholimbana ndi mikhalidwe yowonongekayi yomwe imakhudza anthu ambiri okalamba.

Njira yathanzi imeneyi imatsegula mwayi womwe njira zamankhwala zamtunduwu sizinawunikirepo. Ngati mukufuna kugula Urolithin A powder / Urolithin A 8-Methyl Ether powder, AASraw mwina chisankho chabwino.

Kufotokozera kwa Urolithin B

Urolithin B ndi urolithin, mtundu wa mankhwala ochulukitsa omwe amapangidwa m'matumbo amunthu atamwa chakudya cha ellagitannins monga makangaza, sitiroberi, raspberries wofiyira, walnuts kapena vinyo wofiira wazaka. Urolithin B amapezeka mkodzo mumtundu wa urolithin B glucuronide.

Urolithin B ndichinthu chachilengedwe chomwe chimakhala ndi zochita za antiproliferative komanso antioxidant. Urolithin B imapangidwa ndi metabolism kuchokera ku polyphenols omwe amapezeka mtedza ndi zipatso, makamaka makangaza. Urolithin B yawonetsedwa kuti idutsa chotchinga chaubongo wamagazi, ndipo itha kukhala ndi zoteteza ku matenda a Alzheimer's.

Njira ya Urolithin B

Amachepetsa kuwonongeka kwa mapuloteni ndipo amachititsa kuti thupi likhale ndi hypertrophy. Urolithin B imaletsa ntchito ya aromatase, enzyme yomwe imasinthitsa estrogen ndi testosterone.

Urolithin B ndi mankhwala achilengedwe omwe ali ndi antiproliferative ndi antioxidant. Urolithin B imapangidwa ndi metabolism kuchokera ku polyphenols omwe amapezeka mtedza ndi zipatso, makamaka makangaza. Urolithin B yawonetsedwa kuti idutsa chotchinga chaubongo wamagazi, ndipo itha kukhala ndi zoteteza ku matenda a Alzheimer's.

Urolithin B imalepheretsa zochitika za NF-κB pochepetsa phosphorylation ndikuwonongeka kwa I VerBcy, ndikupondereza phosphorylation ya JNK, ERK, ndi Akt, ndikukweza phosphorylation ya AMPK. Urolithin B amakhalanso owongolera mafupa am'mimba. Urolithin B ndi amodzi mwamatumbo a michere ya michere ya ellagitannins, ndipo ali ndi zotsutsana ndi zotupa komanso zoteteza ku antioxidant.

Ntchito ya Urolithin B.

Pofufuza za anti-inflammatory and antioxidant properties of urolithins A ndi B, ofufuza a UCL adazindikira kuti omalizirayo amateteza minofu. Maselo amisempha pachikhalidwe omwe amalumikizana ndi urolithin B adakula kuposa omwe sanali. Tinkafuna kudziwa chifukwa chake.

Choyamba, adaphunzira za vitro ndikupeza kuti urolithin B imakhudza kawiri: imathandizira kuphatikizika kwa mapuloteni ndikuchepetsa kuwonongeka.

Chachiwiri, ofufuzawo adaphunzira momwe urolithin B amagwirira ntchito mu vivo, pa mbewa. 'Zawonjezera kukula kwa minofu yawo', Prof. Francaux akuti. 'Tidaperekanso mbewa ndi mitsempha yoduka yomwe imayambitsa ziwalo za mwendo, ndipo kutayika kwa minofu komwe kunachitika kunachitika 20 mpaka 30% posachedwa komanso pang'ono pang'ono.'

Zotsatira za Urolithin B.

Urolithin B ndi amodzi mwamatumbo a michere ya ellagitannins, ndipo ali ndi zotsutsana ndi zotupa komanso zoteteza ku antioxidant. Urolithin B imalepheretsa zochitika za NF-κB pochepetsa phosphorylation ndikuwonongeka kwa I VerBcy, ndikupondereza phosphorylation ya JNK, ERK, ndi Akt, ndikukweza phosphorylation ya AMPK. Urolithin B imakhalanso wolamulira mafupa a minofu.

(1). Urolithin B amachepetsa kuchepa kwa kulemera kwa minofu komwe kumayambitsidwa ndi kudziwonetsera
(2). Urolithin B-yolowetsa mafupa a hypertrophy mu mbewa
(3). Mphamvu ya anabolic ya urolithin B imasinthidwa ndi receptor ya androgen
(4). Urolithin B imayambitsa mapuloteni mu C2C12 myotubes poyambitsa chizindikiro cha mTORC1
(5). Urolithin B imalepheretsa kuwonongeka kwa mapuloteni pochepetsa ubiquitin-proteasome njira
(6). Urolithin B imathandizira kusiyanitsa kwa myotubes ya C2C12

Tsamba:

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