Mafotokozedwe Akatundu
Vardenafil Hydrochloride Kanema waufa-AASraw
yaiwisi Vardenafil HCL Makhalidwe Oyambira Ufa
| Name: | Vardenafil hydrochloride (Levitra) powder |
| CAS: | 224785-91-5 |
| Maselo chilinganizo: | C22H19N3O4 |
| Kulemera kwa Maselo: | 389.4 |
| Melt Point: | 298-300 ° C |
| Kusungirako nyengo: | 20ºC |
| mtundu; | Poda Yoyera |
Kodi Vardenafil hydrochloride Powder ndi chiyani?
Vardenafil hydrochloride powder, wotchedwanso vardenafil HCL ufa, ndi imodzi mwa enzyme phosphodiesterase mtundu wa 5 (PDE5Enzyme iyi imayambitsa kuwonongeka kwa cyclic guanosine monophosphate (cGMP), molekyulu yomwe imagwira ntchito yofunika kwambiri pakupanga erectile.
Panthawi yogonana, nitric oxide imatulutsidwa mu minofu ya erectile ya mbolo (corpus cavernosum), yomwe imapangitsa kuti enzyme guanylate cyclase. minyewa iyi imalola magazi ochulukirapo kulowa mu mbolo, zomwe zimatsogolera ku erection.
Poletsa PDE5, AASraw vardenafil hydrochloride powder imalepheretsa kuwonongeka kwa cGMP, motero kusunga mlingo wapamwamba wa molekyuluyi ndikuwonjezera zotsatira zake.Izi zimapangitsa kuti minofu ikhale yopumula komanso kutuluka kwa magazi, potero kuthandizira kukonza erection panthawi yogonana.
Kodi Vardenafil hydrochloride Powder amagwira ntchito bwanji?
Vardenafil hydrochloride powder amagwira ntchito ngati choletsa chosankha cha enzyme yotchedwa phosphodiesterase type 5 (PDE5) .
①Kukondoweza pakugonana kumayambitsa kutulutsa kwa nitric oxide mu corpus cavernosum, dera la mbolo.
②Nitric oxide iyi imayambitsa puloteni yotchedwa guanylate cyclase kuti isinthe guanosine triphosphate (GTP) kukhala cyclic guanosine monophosphate (cGMP).
③CGMP imapangitsa kuti minofu yosalala mu corpus cavernosum ipumule, zomwe zimapangitsa kuti mitsempha ya magazi iwonongeke.
④Kufutukuka kwa mitsempha yamagazi kumawonjezera kuthamanga kwa magazi kulowa mbolo, zomwe zimatsogolera ku erection.
⑤Kawirikawiri, enzyme PDE5 imaphwanya cGMP, kutha erection.Vardenafil hydrochloride amagwira ntchito poletsa zochita za PDE5, motero amalola cGMP kukhala nthawi yayitali ndikutalikitsa erection.
⑥Pamapeto pake, vardenafil hydrochloride imathandizira ndikusunga njira yachilengedwe yomwe imatsogolera ku erection poyankha kukopa kwa kugonana.
Ndikofunika kumvetsetsa kuti vardenafil hydrochloride sichimayambitsa erection mwachindunji.M'malo mwake, imapangitsa kuti thupi likhale logwirizana ndi chilakolako chogonana.Komanso, ndikofunika kugula vardenafil hydrochloride powder kuchokera kwa ogulitsa odalirika monga AASraw, omwe apereka verdenafil hcl powder kwa ambiri. zaka.
Vardenafil VS.Avanafil VS.Tadalafil VS.Sildenafil
Zida zinayi zodziwika bwino za PDE5 inhibitors pamsika ndi sildenafil,tadalafilvardenafil, ndi chithu.Mamankhwala anayiwa ndi onse PDE5 inhibitors ndipo ndiwo mzere woyamba wa chithandizo cha ED.Komabe, mapangidwe a molekyulu a mankhwala anayiwa amasiyana, zomwe zimapangitsa kuti pakhale zochitika zosiyanasiyana za mankhwala ndi zakuthupi.Chotsatira chake, kuyamwa kwawo, kugawa, kugawanika, ndi metabolism. excretion m'thupi zimasiyanasiyana, monga momwe amachiritsira.
| PDE5 Inhibitor | Chiyambi Chake | Tmax (h) | Cmax (ng/ml) | T1/2 (h) | Nthawi (h) | Zoyipa Zazikulu |
| Siligalafil | 30 min-1h | 0.8-1 | 560 | 2.6-3.7 | 4 | Kupweteka kwa mutu, kupukuta kumaso, kusadya chakudya, kutsekeka m'mphuno, chizungulire, kusawona bwino |
| Vardenafil | 15 Mph | 0.9 | 200 | 3.9 | 8 | Kupweteka kwa mutu, kupukuta kumaso, kusadya chakudya, kutsekeka m'mphuno, chizungulire, kusawona bwino |
| Tadalafil | 1h | 2 | 378 | 17.5 | 36 | Mutu, kupukuta kumaso, kusadya bwino, kutsekeka kwa m'mphuno, chizungulire, kusawona bwino |
| Avanafil | 10-15 min | / | > 1000 | 3-5 | 6-8 | Kupweteka kwa mutu, kupukuta kumaso, kusagaya chakudya, kupindika m'mphuno, chizungulire (kawirikawiri poyerekeza ndi ena) |
Zindikirani:
Tmax = nthawi yofikira ndende yayikulu ya plasma
Cmax = kuchuluka kwa plasma ndende
T1/2 = theka la moyo
Gome ili likufotokozera mwachidule makhalidwe a pharmacokinetic a PDE5 inhibitors anayi omwe amakambidwa.Nthawi zonse ndizofunikira kuti opereka chithandizo chamankhwala aganizire kusiyana kumeneku popereka mankhwalawa, ndipo odwala ayenera kugwiritsa ntchito mankhwalawa nthawi zonse moyang'aniridwa ndi dokotala.Kuonjezera apo, kugula vardenafil hcl ufa kuchokera ku Wodalirika wodalirika monga AASraw amakutsimikizirani kuti mumalandira mankhwala abwino kwambiri komanso oyera.AASraw, monga katswiri wa vardenafil hcl powder supplier, akhoza kupereka vardenafil hydrochloride powder ndi apamwamba kwambiri padziko lonse lapansi.
Momwe mungasankhire PDE5 inhibitors?
Kusankha PDE5 inhibitor yoyenera kungadalire zinthu zosiyanasiyana, kuphatikizapo thanzi la wodwalayo, kukhalapo kwa mikhalidwe ina, moyo wawo, ndi momwe amayankhira mankhwala. nthawi zonse kukaonana ndi wothandizira zaumoyo kuti apange chisankho chabwino pa zosowa za munthu payekha.
| Mkhalidwe Wodwala | Analimbikitsa PDE5 Inhibitor | chifukwa |
| Kufufuza kwa nthawi yoyamba | Avanafil | Kuyamba kofulumira kwambiri pakati pa PDE5 inhibitors |
| Azaka zapakati ndi okalamba omwe ali ndi ED ndi matenda osatha (kuthamanga kwa magazi, hyperlipidemia) | Siligalafil | Avereji magawo a pharmacokinetic, kukondoweza pang'ono kwa thupi |
| Azaka zapakati ndi okalamba omwe ali ndi ED ndi vuto la vascular endothelial dysfunction (mwachitsanzo, shuga) | Tadalafil | Kutalika kwa nthawi yochitapo kanthu, kumatha kupititsa patsogolo ntchito ya mtima endothelial ndi zizindikiro za mkodzo pakapita nthawi |
| Azaka zapakati komanso okalamba omwe ali ndi ED, palibe matenda amtima | Vardenafil | Zotsatira zochepa, kuyambika mwachangu, kutsika kwa bioavailability, zoyipa zochepa |
| Azaka zapakati ndi okalamba omwe ali ndi ED, vascular endothelial dysfunction, sildenafil osagwira ntchito | Avanafil | Mkulu magazi ndende, amphamvu zotsatira |
| Achinyamata ndi azaka zapakati ndi ED, palibe chodziwikiratu cha organic etiology | Siligalafil | Zothandiza pa ED yoyambitsidwa ndi zinthu zamaganizidwe |
| Kuwoneka kosawoneka bwino komanso ED | Tadalafil | Palibe zowoneka bwino pakati pa zoyipa |
| Kukonda mankhwala a Postprandial | Avanafil, Vardenafil | Kuchuluka kwa mayamwidwe sikukhudzidwa mosavuta ndi chakudya |
Zindikirani: Zambiri zokhudza PDE5 inhibitors zimaperekedwa kuti zidziwitse zambiri zokhazokha ndipo sizipanga uphungu wachipatala.Kusankha kwa PDE5 inhibitor kuyenera kuchitidwa nthawi zonse pokambirana ndi wothandizira zaumoyo yemwe angaganizire za thanzi la munthu, mankhwala ena. kutengedwa, ndi chikhalidwe chenichenicho ndi kuopsa kwa vuto la erectile.Ngakhale kuti mankhwalawa angakhale othandiza pochiza vuto la erectile, amakhalanso ndi zotsatirapo komanso zoopsa zomwe zingatheke, ndipo sali oyenera kwa aliyense.Zikhalidwe zina zaumoyo ndi mankhwala ena angagwirizane nawo. PDE5 inhibitors, zomwe zimabweretsa zotsatira zoyipa kwambiri. Nthawi zonse funsani upangiri wa azachipatala pa mafunso aliwonse omwe mungakhale nawo okhudzana ndi matenda.
Mlingo ndi kayendetsedwe ka Vardenafil hydrochloride Powder kuti afotokoze
Mlingo wa vardenafil HCL ufa ukhoza kusiyana malinga ndi thanzi la munthu, kuyankha kwa mankhwala, ndi mankhwala ena omwe angakhale akumwa.Pano pali malingaliro ambiri, koma ndikofunikira kutsatira malangizo enieni a wothandizira zaumoyo wanu.
①Standard dose kwa echokwawa dntchito
Mlingo woyambira wa vardenafil ndi 10 mg, womwe umatengedwa pamlomo pafupifupi mphindi 60 musanayambe kugonana. patsiku.
②Odwala moderate hwokondwa ikuwonongeka
Kwa odwala omwe ali ndi vuto la hepatic (Child-Pugh B), mlingo woyambira wa 5 mg wa vardenafil umalimbikitsidwa.
③Odwala skonse rena ikuwonongeka
Kwa odwala omwe ali ndi vuto lalikulu (CLcr <30 mL/min) aimpso, mlingo woyambira wa 5 mg wa vardenafil ukulimbikitsidwa.
④Odwala pa sgome alpha-bloka tmankhwala
Mlingo woyambira wa vardenafil kwa odwala omwe amalandira chithandizo chokhazikika cha alpha-blocker ndi 5 mg.
⑤Odwala concomitant uChithunzi cha CYP3A4 izoletsa
Kwa odwala omwe amatenga zoletsa zamphamvu za CYP3A4 (monga ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, ndi atazanavir), mlingo woyamba wa 5 mg vardenafil sayenera kupitirira.
zolemba
Ndikofunika kuzindikira kuti kukakamiza kugonana kumafunika kuti munthu ayankhe chithandizo chamankhwala.Vardenafil sichimawonjezera chilakolako cha kugonana ndipo sichidzatulutsa erection popanda kugonana. mankhwala omwe angathandize kuti akwaniritse bwino ntchito yake.AASraw ikufuna kupereka ufa wapamwamba wa vardenafil hcl padziko lonse pansi pa malamulo a CGMP.Ngati muli ndi zosowa, AASraw ndi chisankho chabwino chogula vardenafil hcl powder.
Kodi mungagule kuti Vardenafil hydrochloride Powder?
Vardenafil hydrochloride ufa ukhoza kugulidwa kuchokera kwa osiyanasiyana ogulitsa pa intaneti omwe amadziwika kwambiri pogulitsa mankhwala opangira mankhwala.Posankha kugula kuchokera kwa ogulitsa pa intaneti, ndikofunika kutsimikizira kuti iwo ndi gwero lodalirika, chifukwa cha kufunika kwa khalidwe ndi chiyero cha Kuonetsetsa kuti wogulitsa amapereka ndondomeko ya mankhwala ndi zikalata zotsimikizira za khalidwe, monga Satifiketi ya Analysis.
Ngati mukufuna gwero lodalirika logulira ufa wa vardenafil,AASraw ikhoza kukhala njira yabwino.AASraw ndi kampani yomwe imapereka mankhwala opangira mankhwala opangira mankhwala, kuphatikizapo vardenafil powder.Zogulitsa zawo zimagwiritsidwa ntchito ndi ma laboratory ndi mabungwe ofufuza kuti apange ndi kupanga zinthu zosiyanasiyana za thanzi.
yaiwisi Vardenafil HCL Lipoti Loyesa Ufa-HNMR
Kodi HNMR ndi chiyani ndipo HNMR sipekitiramu imakuuzani chiyani? H Nuclear Magnetic Resonance (NMR) spectroscopy ndi njira yowunikira ya chemistry yomwe imagwiritsidwa ntchito poyang'anira zabwino ndi kafukufuku kuti adziwe zomwe zili ndi kuyera kwa sampuli komanso kapangidwe kake ka maselo. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR itha kugwiritsidwa ntchito kuti ifanane ndi malaibulale owoneka bwino kapena kutsimikizira kapangidwe kake mwachindunji. Mapangidwe oyambira akadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe mamolekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa maselo monga kusinthana kosinthika, kusintha kwa magawo, kusungunuka, ndi kufalikira.
Vardenafil Hydrochloride powder (224785-91-5) -COA
Vardenafil Hydrochloride powder (224785-91-5) -COA
Kodi mungagule bwanji Vardenafil HCL Powder kuchokera ku AASraw?
❶Kuti mutitumizire kudzera pa imelo yathu yofunsira, kapena kutisiyira nambala yanu ya whatsapp, woimira makasitomala athu (CSR) azilumikizana nanu m'maola 12.
❷Kutipatsirani kuchuluka kwanu ndi adilesi yomwe mwafunsidwa.
❸CSR yathu idzakupatsani nthawi yowerengera, nthawi yolipira, nambala yotsatirira, njira zobweretsera komanso tsiku loti mudzafike (ETA).
❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.
❺Katundu wolandilidwa ndi kupereka ndemanga.
Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine
Scientific Journal paper Wolemba:
1. CC Carson
Dipatimenti ya Opaleshoni, Division of Urology, University of North Carolina, Chapel Hill, NC,
2. I. Eardley
Chipatala cha St. James' University, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, USA
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, USA
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza, kuvomereza ndi kuyamika ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.
Reference
[1] Aversa A,Pili M,Francomano D,Bruzziches R,Spera E,La Pera G,Spera G (July 2009). "Zotsatira za vardenafil administration pa intravaginal ejaculatory latency time mwa amuna omwe ali ndi moyo wautali wautali". Magazini ya International Journal of Impotence Research. 21 ( 4 ): 221-7 .
[2] Schools of Pharmacy (Glen L.Stimmel,D.,ndi Mary A.Gutierrez,Pharm.D.) ndi Medicine (Glen L.Stimmel,Pharm.D.),University of Southern California,Los Angeles,California. "Kupereka Uphungu kwa Odwala Pankhani Zogonana: Kudzidalira Kwambiri Kumayambitsa Mankhwala Osokoneza Bongo" .Medscape.Retrieved 2010-12-06.
[3] "Chithandizo chatsopano cha erectile dysfunction Staxyn chovomerezeka ku US.-Kupanga Mankhwala ". kathakal.2010-06-21.Zosungidwa kuchokera koyambirira pa 2012-04-06.
[4] Tucker J,Fischer T,Upjohn L,Mazzera D,Kumar M (October 2018). "Zosakaniza Zamankhwala Zosavomerezeka Zomwe Zimaphatikizidwa M'zakudya Zowonjezera Zogwirizana ndi Machenjezo a US Food and Drug Administration". JAMA Network Open. 1(6):
[5] Lepor H,Lepor NE,Hill LA,Trohman RG (2008). "The QT Interval ndi Kusankhidwa kwa Alpha-Blockers kwa Benign Prostatic Hyperplasia". Ndemanga mu Urology. 10 (2):85–91.
