Vardenafil HCL ufa

Vardenafil Hydrochloride Kanema waufa-AASraw

yaiwisi Vardenafil HCL Makhalidwe Oyambira Ufa

Kodi Vardenafil hydrochloride Powder ndi chiyani?

Vardenafil hydrochloride powder, wotchedwanso vardenafil HCL ufa, ndi imodzi mwa enzyme phosphodiesterase mtundu wa 5 (PDE5) zoletsa. Enzyme iyi imayambitsa kuwonongeka kwa cyclic guanosine monophosphate (cGMP), a molekyu yomwe imagwira ntchito yofunika kwambiri mu njira ya erectile.

Panthawi yogonana, nitric oxide imatulutsidwa mu minofu ya erectile ya mbolo (corpus cavernosum), yomwe imayambitsa enzyme guanylate cyclase. Enzyme iyi imakulitsa milingo ya cGMP, yomwe imatsitsimutsanso maselo osalala a minofu mu corpus cavernosum. Kupumula kwa minofuyi kumapangitsa kuti magazi ambiri azilowa mu mbolo, zomwe zimatsogolera ku erection.

Poletsa PDE5, AASraw vardenafil hydrochloride ufa imalepheretsa kuwonongeka kwa cGMP, motero kusunga milingo yapamwamba ya molekyulu iyi ndikutalikitsa zotsatira zake. Izi zimapangitsa kuti minofu ikhale yopumula komanso magazi aziyenda bwino, motero zimathandiza kukonza erection panthawi yogonana.

Kodi Vardenafil hydrochloride Powder amagwira ntchito bwanji?

Vardenafil hydrochloride powder amagwira ntchito ngati choletsa chosankha cha enzyme yotchedwa phosphodiesterase type 5 (PDE5). Nayi a mwatsatane-tsatane kalozera momwe zimagwirira ntchito:

①Kukondoweza pakugonana kumayambitsa kutulutsidwa kwa nitric oxide mu corpus cavernosum, dera la mbolo.

②Nitric oxide iyi imayambitsa puloteni yotchedwa guanylate cyclase kuti isinthe guanosine triphosphate (GTP) kukhala cyclic guanosine monophosphate (cGMP).

③CGMP imapangitsa kuti minofu yosalala mu corpus cavernosum ipumule, zomwe zimapangitsa kuti mitsempha ya magazi iwonongeke.

④Kufalikira kwa mitsempha yamagazi kumawonjezera kuthamanga kwa magazi kulowa mbolo, zomwe zimapangitsa kuti iume.

⑤Nthawi zambiri, puloteni ya PDE5 imaphwanya cGMP, kutsiriza erection. Vardenafil hydrochloride amagwira ntchito poletsa zochita za PDE5, motero amalola cGMP kukhala nthawi yayitali ndikuwonjezera erection.

⑥Pamapeto pake, vardenafil hydrochloride imathandizira ndikusunga njira yachilengedwe yomwe imatsogolera ku erection poyankha kukopa kwa kugonana.

Ndikofunika kumvetsetsa kuti vardenafil hydrochloride sichimayambitsa erection mwachindunji. M'malo mwake, izo kumawonjezera kuyankhidwa kwachilengedwe kwa thupi pakugonana kukondoweza. Komanso, ndikofunikira kugula vardenafil hydrochloride ufa kuchokera kwa wothandizira wodalirika monga AASraw, yemwe wapereka ufa wa vardenafil hcl kwa zaka zambiri.

Vardenafil VS.Avanafil VS.Tadalafil VS.Sildenafil

Zida zinayi zodziwika bwino za PDE5 inhibitors pamsika ndi sildenafil, tadalafil, vardenafil, ndi chithu. Mankhwala anayiwa onse ndi PDE5 inhibitors ndipo ndiwo mzere woyamba wamankhwala a ED. Komabe, mapangidwe a mamolekyu a mankhwala anayiwa amasiyana, zomwe zimapangitsa kuti pakhale zinthu zosiyanasiyana komanso zakuthupi. Zotsatira zake, kuyamwa kwawo, kugawa, kagayidwe, ndi kutuluka m'thupi kumasiyana, monga momwe amachiritsira.

Zindikirani:

Tmax = nthawi yofikira ndende yayikulu ya plasma

Cmax = kuchuluka kwa plasma ndende

T1/2 = theka la moyo

Gome ili likufotokozera mwachidule mawonekedwe a pharmacokinetic a ma inhibitors anayi a PDE5 omwe akukambidwa. Nthawi zonse ndikofunikira kuti othandizira azaumoyo aziganizira za kusiyana kumeneku popereka mankhwalawa, ndipo odwala ayenera kugwiritsa ntchito mankhwalawa moyang'aniridwa ndi dokotala. Komanso, kugula vardenafil hcl ufa kuchokera kwa ogulitsa odalirika monga AASraw zimakutsimikizirani kuti mwalandira chinthu chapamwamba kwambiri komanso choyera. AASraw, monga katswiri wa vardenafil hcl powder supplier, akhoza kupereka vardenafil hydrochloride powder ndi apamwamba kwambiri padziko lonse lapansi.

Momwe mungasankhire PDE5 inhibitors?

Kusankha PDE5 inhibitor yoyenera kungadalire pazifukwa zosiyanasiyana, kuphatikizapo thanzi la wodwalayo, kukhalapo kwa zinthu zina, moyo wawo, ndi momwe amayankhira mankhwala. Nayi chitsogozo chosankha PDE5 inhibitor kuti mufotokozere, koma kumbukirani nthawi zonse kukaonana ndi azaumoyo kuti mupange chisankho chabwino pazosowa zanu.

Zindikirani: Izi za PDE5 inhibitors zimaperekedwa kuti zidziwitse zambiri zokha ndipo sizipanga upangiri wachipatala. Kusankhidwa kwa PDE5 inhibitor kuyenera kupangidwa nthawi zonse pokambirana ndi wothandizira zaumoyo yemwe angaganizire za thanzi la munthu, mankhwala ena omwe amamwa, komanso chikhalidwe chenichenicho ndi kuopsa kwa erectile kukanika. Ngakhale mankhwalawa amatha kukhala othandiza pochiza vuto la erectile, amakhalanso ndi kuthekera zotsatira zoyipazi ndi zoopsa, ndipo sizoyenera aliyense. Matenda ena ndi mankhwala ena amatha kuyanjana ndi PDE5 inhibitors, zomwe zimayambitsa zotsatira zowopsa. Nthawi zonse funsani upangiri wa azachipatala pa mafunso aliwonse omwe mungakhale nawo okhudzana ndi matenda.

Mlingo ndi kayendetsedwe ka Vardenafil hydrochloride Powder kuti afotokoze

The mlingo wa vardenafil HCL ufa zingasiyane malinga ndi thanzi la munthuyo, mmene munthu angayankhire mankhwala, ndi mankhwala ena amene angakhale akumwa. Nazi malingaliro ambiri, koma ndikofunikira kutsatira malangizo achipatala anu.

①Standard dose kwa echokwawa dntchito

Mlingo woyambira wa vardenafil ndi 10 mg, wotengedwa pamlomo pafupifupi mphindi 60 musanayambe kugonana. Mlingowo ukhoza kuwonjezeka kufika pa 20 mg kapena kutsika mpaka 5 mg, kutengera mphamvu ya munthu ndi kulolera. Pazipita analimbikitsa mlingo pafupipafupi ndi kamodzi patsiku.

②Odwala moderate hwokondwa ikuwonongeka

Kwa odwala omwe ali ndi vuto la chiwindi (Child-Pugh B), mlingo woyambira wa 5 mg wa vardenafil ukulimbikitsidwa. Mlingo waukulu kwa odwala omwe ali ndi vuto la chiwindi lokhazikika sayenera kupitirira 10 mg.

③Odwala skonse rena ikuwonongeka

Kwa odwala omwe ali ndi vuto lalikulu (CLcr <30 mL / min) aimpso, mlingo woyambirira wa 5 mg wa vardenafil ukulimbikitsidwa.

④Odwala pa sgome alpha-bloka tmankhwala

Mlingo woyambira wa vardenafil kwa odwala omwe amalandira chithandizo chokhazikika cha alpha-blocker ndi 5 mg.

⑤Odwala concomitant uChithunzi cha CYP3A4 izoletsa

Kwa odwala omwe amatenga zoletsa zamphamvu za CYP3A4 (monga ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, ndi atazanavir), mlingo woyambirira wa 5 mg vardenafil sayenera kupitilira.

zolemba

Ndikofunika kuzindikira kuti kukondoweza kwa kugonana kumafunika poyankha chithandizo. Vardenafil sichimawonjezera chilakolako cha kugonana ndipo sichidzatulutsa erection popanda chilakolako chogonana. Kugula vardenafil HCL ufa kuchokera kwa wothandizira wodalirika akhoza kuonetsetsa kuti mukulandira mankhwala apamwamba kwambiri omwe angathandize kuti akwaniritse bwino ntchito yake.AASraw ikufuna kupereka ufa wapamwamba wa vardenafil hcl padziko lonse pansi pa malamulo a CGMP. Ngati muli ndi zosowa, AASraw ndi chisankho chabwino kwambiri chogula vardenafil hcl ufa.

Kodi mungagule kuti Vardenafil hydrochloride Powder?

Vardenafil hydrochloride ufa ukhoza kugulidwa kuchokera kwa ogulitsa osiyanasiyana pa intaneti omwe amadziwika kwambiri pogulitsa mankhwala opangira mankhwala. Posankha kugula kuchokera kwa ogulitsa pa intaneti, ndikofunikira kutsimikizira kuti ndi gwero lodziwika bwino, poganizira kufunikira kwa mtundu ndi chiyero cha mankhwala zofunsira zaumoyo. Onetsetsani kuti wogulitsa akupereka mankhwala specifications ndi khalidwe zikalata zotsimikizira, monga Certificate of Analysis.

Ngati mukufuna gwero lodalirika logulira ufa wa vardenafil, AASraw ikhoza kukhala njira yoyenera.AASraw ndi kampani yomwe imapereka mitundu yambiri ya mankhwala zida zogwiritsira ntchito, kuphatikizapo vardenafil ufa. Zogulitsa zawo zimagwiritsidwa ntchito ndi ma laboratories ndi mabungwe ofufuza popanga ndi kupanga zinthu zosiyanasiyana zaumoyo.

yaiwisi Vardenafil HCL Lipoti Loyesa Ufa-HNMR

Kodi HNMR ndi chiyani ndipo mawonekedwe a HNMR amakuuzani chiyani? H Nuclear Magnetic Resonance (INMR) spectroscopy ndi njira yowunikira yomwe imagwiritsidwa ntchito poyang'anira khalidwe ndi kufufuza kuti mudziwe zomwe zili ndi kuyera kwa chitsanzo komanso momwe maselo ake amapangidwira. Mwachitsanzo, NMR imatha kusanthula mochulukira zosakaniza zomwe zili ndi mankhwala odziwika. Pazinthu zosadziwika, NMR ingathe (mwina kugwiritsidwa ntchito kufananiza ndi malaibulale owoneka bwino kapena kutengera kapangidwe kake mwachindunji. Kapangidwe koyambira kadziwika, NMR itha kugwiritsidwa ntchito kudziwa momwe ma molekyulu amathandizira komanso kuphunzira zakuthupi pamlingo wa mamolekyulu. monga kusinthana kwa conformational, kusintha kwa gawo, kusungunuka, ndi kufalikira.

Vardenafil Hydrochloride powder (224785-91-5) -COA

Vardenafil Hydrochloride powder (224785-91-5) -COA

Kodi mungagule bwanji Vardenafil HCL Powder kuchokera ku AASraw?

❶Ku kukhudzana ndi njira yathu yofunsira maimelo, kapena kutisiyira nambala yanu ya WhatsApp, woimira makasitomala athu (CSR) adzakulumikizani m'maola 12.

❷Kutipatsirani kuchuluka komwe mwafunsidwa ndi adilesi yanu.

❸CSR yathu idzakupatseni quotation, nthawi yolipira, nambala yotsatirira, njira zobweretsera, ndi tsiku loti mudzafike (ETA).

❹Ndalipira ndipo katundu adzatumizidwa mkati mwa maola 12.

❺Katundu wolandilidwa ndi kupereka ndemanga.

Wolemba nkhaniyi:
Dr. Monique Hong adamaliza maphunziro awo ku UK Imperial College London Faculty of Medicine

Scientific Journal paper Wolemba:
1. Hazem M. Abu Shawish
Chemistry department, College of Sciences, Al-Aqsa University, Gaza, Palestine
2. E. BISCHOFF
Kuchokera ku Institute of Cardiovascular Research II, ndi Madipatimenti a Chemical Research, and Product Development and Preclinical Pharmacokinetics, BAYER AG Pharmaceutical Business Group, Wuppertal, Germany
3. MM Mabrouk
Dipatimenti ya pharmaceutical analytical chemistry, faculty of pharmacy, yunivesite ya Tanta, Tanta, Egypt
4. Engin Yurtcu
Dipatimenti ya Obstetrics and Gynecology ku Zekai Tahir Burak Women's Health and Research Hospital, Ankara, Turkey
5. Silvia Limoncella
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena ndi Reggio Emilia, Modena, Italy
Dokotala/wasayansiyu savomereza kapena kulimbikitsa kugula, kugulitsa, kapena kugwiritsa ntchito mankhwalawa pazifukwa zilizonse. Aasraw alibe chiyanjano kapena ubale, wonenedwa kapena ayi, ndi dokotala uyu. Cholinga chotchula dokotalayu ndikuvomereza ndikuyamikira ntchito yofufuza ndi chitukuko yomwe asayansi akugwira ntchitoyi.

Reference

[1] Aversa A,Pili M,Francomano D,Bruzziches R,Spera E,La Pera G,Spera G (July 2009). "Zotsatira za vardenafil administration pa intravaginal ejaculatory latency time mwa amuna omwe ali ndi moyo wautali wautali". Magazini ya International Journal of Impotence Research. 21 ( 4 ): 221-7 . 

[2] Schools of Pharmacy (Glen L.Stimmel,D.,ndi Mary A.Gutierrez,Pharm.D.) ndi Medicine (Glen L.Stimmel,Pharm.D.),University of Southern California,Los Angeles,California. "Kupereka Uphungu kwa Odwala Pankhani Zogonana: Kudzidalira Kwambiri Kumayambitsa Mankhwala Osokoneza Bongo" .Medscape.Retrieved 2010-12-06.

[3] "Chithandizo chatsopano cha erectile dysfunction Staxyn chovomerezeka ku US.-Kupanga Mankhwala ". kathakal.2010-06-21.Zosungidwa kuchokera koyambirira pa 2012-04-06.

[4] Tucker J,Fischer T,Upjohn L,Mazzera D,Kumar M (October 2018). "Zosakaniza Zamankhwala Zosavomerezeka Zomwe Zimaphatikizidwa M'zakudya Zowonjezera Zogwirizana ndi Machenjezo a US Food and Drug Administration". JAMA Network Open. 1(6): 

[5] Lepor H,Lepor NE,Hill LA,Trohman RG (2008). "The QT Interval ndi Kusankhidwa kwa Alpha-Blockers kwa Benign Prostatic Hyperplasia". Ndemanga mu Urology. 10 (2):85–91.

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