Mafunso Ofunsidwa Kawirikawiri Ponena za Sunitinib Malate 丨 AASraw
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Suntinib Malate

 

  1. Zowona za Sunitinib Malate
  2. Kodi Titha Kugwiritsa Ntchito Malititi a Sunitinib?
  3. Momwe Sunitinib Malate Imagwirira Ntchito?
  4. Momwe Mungatengere Sunitinib Malate?
  5. Momwe Mungasungire Sunitinib Malate?
  6. Kodi Timadziwa Zambiri Zotani Zoyipa Za Sunitinib Malate?
  7. Ndi Mankhwala Ena ati Omwe Angakhudze Sunitinib Malate?
  8. FDA imavomereza Sunitinib Malate Monga Adjuvant Treatment Ya Renal Cell Carcinoma
  9. Ndingagule Kuti Kuti Sunitinib Malate Paintaneti?

 

Malangizo a Sunitinib (CAS:341031-54-7) idapezeka ku SUGEN, kampani yopanga biotechnology yomwe idapanga protein kinase inhibitors. Anali wachitatu pamankhwala angapo kuphatikiza SU5416 ndi SU6668. Lingaliroli linali la kutengera kwa ATP komwe kungapikisane ndi ATP pakumanga tsamba lothandizira la receptor tyrosine kinases. Lingaliro ili lidapangitsa kuti apange ma molekyulu ambiri a tyrosine kinase inhibitors, kuphatikiza Gleevec, Sutent, Tarceva ndi ena ambiri.

 

Zowona za Sunitinib Malate

Sunitinib Malate ndi ufa wachikasu mpaka lalanje. Sunitinib Malate ndi tinthu tating'onoting'ono tating'onoting'ono tambiri cholandila tyrosine kinase (RTK) choletsa. Pa Januware 26, 2006, wothandizirayo adavomerezedwa ndi US FDA pazizindikiro zakuchiritsa renal cell carcinoma (RCC) ndi imatinib zosagwira m'mimba stromal chotupa (GIST). Pazinthu izi, Sunitinib Malate nthawi zambiri imapezeka ngati kapangidwe kovomerezeka pakamwa. Sunitinib Malate imalepheretsa kusaina kwama foni powunikira ma RTK angapo. Izi zikuphatikiza zonse zopangidwa ndi ma platelet-factor factor receptors (PDGF-R) ndi vasot endothelial grow factor receptors (VEGF-R). Sunitinib Malate imaletsanso KIT (CD117), RTK yomwe imayendetsa ma GIST ambiri. Kuphatikiza apo, Sunitinib Malate imaletsa ma RTK ena kuphatikiza RET, CSF-1R, ndi flt3.

 

Kodi Titha Kugwiritsa Ntchito Malititi a Sunitinib? 

Sunitinib Malate imagwiritsidwa ntchito pochiza achikulire omwe ali ndi khansa ya impso yomwe siinafalikire (komweko) komanso omwe ali pachiwopsezo chachikulu kuti RCC ibwererenso atachitidwa opaleshoni ya impso.

Sunitinib Malate imagwiritsidwa ntchito pochiza khansa yapakati ya impso (renal cell carcinoma kapena RCC).

Sunitinib Malate amagwiritsidwa ntchito pochiza khansa yosowa m'mimba, m'mimba, kapena m'mimba yotchedwa chotupa cham'mimba cham'mimba (GIST) ndipo mutamwa mankhwala imatinib mesylate ndipo sanaimitse khansa kukula kapena simungathe kumwa imatinib mesylate. Gleevec ndi dzina lovomerezeka la Novartis Pharmaceuticals Corporation.

Sunitinib Malate amagwiritsidwa ntchito pochiza khansa yapakirapeni yotchedwa pancreatic neuroendocrine tumors (pNET) yomwe yapita patsogolo ndipo singachiritsidwe ndi opaleshoni.

 

Momwe Sunitinib Malate Imagwirira Ntchito?

Sunitinib Malate ndi tizilombo tating'onoting'ono tating'onoting'ono tating'onoting'ono tating'onoting'ono tating'onoting'ono ta tyrosine kinases, tomwe timakhala tomwe timakhudzidwa ndi kukula kwa chotupa, matenda angiogenesis, komanso kufalikira kwa khansa. Wothandizirayo amaletsa maplatelet-derived kukula factor receptors - (PDGFRcy ndi PDGFRβ), vascular endothelial growth factor receptors (VEGFR1, VEGFR2, ndi VEGFR3), stem cell factor receptor (KIT), FMS-ngati tyrosine kinase 3, colony-stimulating factor receptor mtundu 1, ndi glial cell-line yochokera ku neurotrophic factor receptor (RET). Sunitinib Malate choletsa zochitika ndi magwiridwe antchito a receptor tyrosine kinases awonetsedwa m'mayeso amankhwala am'magulu ndi ma cell komanso kuyesa kuchuluka kwa ma cell. Metabolite yoyamba ya Sunitinib Malate imawonetsera potency yofananira ndi kholo lomwe limayeserera zamagetsi zamagetsi.

Sunitinib Malate imalepheretsa phosphorylation yamagulu angapo a receptor tyrosine kinases (PDGFRβ, VEGFR2, KIT) mu chotupa xenografts chofotokozera zolandilira za tyrosine kinase mu vivo ndipo zimalepheretsa kukula kwa chotupa ndi metastasis mumitundu ina yoyesera. Wothandizirayo amaletsa kukula kwa zotupa zomwe zimafotokoza zolakwika za receptor tyrosine kinases (PDGFR, RET, kapena KIT) mu vitro ndi PDGFRβ-ndi VEGFR2 yotengera chotupa angiogenesis mu vivo.

 

Suntinib Malate

 

Momwe Mungatengere Sunitinib Malate?

Mlingo wa Sunitinib Malate womwe dokotala wanu akukulemberani udalira pazinthu zingapo. Izi zikuphatikiza:

- mtundu ndi kuuma kwa zomwe mukugwiritsa ntchito Sunitinib Malate kuchiza

Conditions matenda ena omwe mungakhale nawo

❸ mankhwala ena omwe mukumwa

Dokotala wanu pomaliza adzakupatsani mlingo wochepa kwambiri womwe umafunikira.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti mukwaniritse zosowa zanu.

 

Forms Mitundu ya mankhwala osokoneza bongo komanso mphamvu zake

Sunitinib Malate imabwera ngati kapisozi komwe mumameza. Amapezeka mu izi: 12.5 milligrams (mg), 25 mg, 37.5 mg, ndi 50 mg.

 

♦ Mlingo wa khansa ya m'mimba

Mlingo wamba wa Sunitinib Malate wa zotupa zam'mimba (GISTs) ndi 50 mg kamodzi patsiku masabata anayi. Pambuyo 4 masabata popanda mankhwala. Kenako, mudzabwereza zozungulira.

Muyenera kupitiliza kumwa Sunitinib Malate mpaka khansa yanu itakula kapena thupi lanu silingalekerere chithandizo ndi mankhwalawa. Dokotala wanu adzazindikira ngati muyenera kusiya kumwa Sunitinib Malate. Kuti mumve zambiri za momwe Sunitinib Malate imagwiritsidwira ntchito kuthana ndi ma GIST, onani ulalo monga pansipa.

 

♦ Mlingo wa khansa ya impso

Sunitinib Malate imagwiritsidwanso ntchito pochiza mtundu wa khansa ya impso yotchedwa advanced renal cell carcinoma (RCC). Mlingo wanthawi zonse wa Sunitinib Malate wa RCC wapamwamba ndi 50 mg kamodzi patsiku kwa masabata 4. Pambuyo 2 masabata popanda mankhwala. Kenako, mudzabwereza zozungulira.

Muyenera kupitiliza kumwa Sunitinib Malate mpaka khansa yanu itakula kapena thupi lanu silingalekerere chithandizo ndi mankhwalawa. Dokotala wanu adzazindikira ngati muyenera kusiya kumwa Sunitinib Malate. Kuti mumve zambiri za momwe Sunitinib Malate imagwiritsidwira ntchito pochizira RCC, onani ulalo monga pansipa.

 

♦ Mlingo wothandizira othandizira khansa ya impso

Sunitinib Malate imagwiritsidwanso ntchito ngati chithandizo chothandizira mtundu wa khansa ya impso yotchedwa RCC pambuyo pa nephrectomy (kuchotsa opaleshoni ya impso). Chizolowezi mlingo wa Suntinib Malate Gwiritsani ntchito 50 mg kamodzi patsiku kwa masabata 4. Pambuyo 2 masabata popanda mankhwala. Mutha kubwereza izi mpaka kasanu ndi kawiri. Kuti mumve zambiri za momwe Sunitinib Malate imagwiritsidwira ntchito ngati chithandizo chothandizira RCC, onani ulalo monga pansipa.

 

Os Mlingo wa khansa ya kapamba

Mlingo wamba wa Sunitinib Malate wa zotupa zapamwamba za pancreatic neuroendocrine (pNETs) ndi 37.5 mg kamodzi patsiku.

Muyenera kupitiliza kumwa Sunitinib Malate mpaka khansa yanu itakula kapena thupi lanu silingalekerere chithandizo ndi mankhwalawa. Dokotala wanu adzazindikira ngati muyenera kusiya kumwa Sunitinib Malate.

 

Odziwika: mlingowo umangotchulidwa, chonde thandizani kuti muwone zambiri patsamba lino:www.fda.gov .

 

AASraw ndiye katswiri wopanga Sunitinib Malate.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Momwe Mungasungire Sunitinib Malate?

Sungani mankhwala awa mu chidebe alowemo, atsekeredwa mwamphamvu, ndipo asapezeke kwa ana. Sungani kutentha kutentha ndi kutali ndi kutentha kwakukulu ndi chinyezi (osati mu bafa).

Ndikofunika kuti mankhwala onse asamaoneke komanso kuti ana azikhala ndi zida zambiri (monga mapiritsi apakati pa mlungu ndi madontho, maso, mavitamini, ndi inhalers) sagonjetsedwa ndi ana ndipo akhoza kuwatsegula mosavuta. Pofuna kuteteza ana aang'ono ku poizoni, nthawi zonse mutseka makapu a chitetezo ndipo nthawi yomweyo perekani mankhwalawa pamalo otetezeka - omwe ali pamwamba ndi kutali ndi osawona ndi kufika.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani Kutaya Kwabwino kwa FDA kwa Webusayiti ya Mankhwala kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

 

Kodi Timadziwa Zambiri Zotani Zoyipa Za Sunitinib Malate?

Zochitika zoyipa za Sunitinib Malate zimawerengedwa kuti zitha kuyendetsedwa ndipo zochitika zazikulu kwambiri zimakhala zochepa.

Zinthu zoyipa kwambiri zomwe zimachitika ndi mankhwala a Sunitinib Malate ndikutopa, kutsegula m'mimba, mseru, anorexia, kuthamanga kwa magazi, khungu lachikaso, khungu lamapazi, ndi stomatitis. Pakafukufuku wowunika kwa placebo Phase III GIST, zovuta zomwe zidachitika kwambiri nthawi zambiri ndi Sunitinib Malate kuposa placebo imaphatikizapo kutsegula m'mimba, anorexia, kutulutsa khungu, mucositis / stomatitis, asthenia, kusintha kwa kukoma, ndi kudzimbidwa. Kuchepetsa kwa mlingo kunkafunika mu 50% mwa odwala omwe amaphunziridwa mu RCC kuti athetse poizoni wothandizirayo.

Zochitika zazikulu (grade 3 kapena 4) zimachitika mu ≤10% ya odwala ndipo zimaphatikizapo kuthamanga kwa magazi, kutopa, asthenia, kutsegula m'mimba, komanso chemotherapy-yomwe imayambitsa acral erythema. Zovuta za labu zomwe zimakhudzana ndi mankhwala a Sunitinib Malate zimaphatikizapo lipase, amylase, neutrophils, lymphocytes, ndi ma platelets. Hypothyroidism ndi erythrocytosis yosinthika idalumikizidwanso ndi Sunitinib Malate. Zochitika zambiri zoyipa zimatha kuyang'aniridwa ndi chisamaliro chothandizira, kusokonezeka kwa mlingo, kapena kuchepetsa mlingo.

Kafukufuku waposachedwa ku MD Anderson Cancer Center anayerekezera zotsatira za odwala khansa ya m'mitsempha ya m'mitsempha omwe adalandira Sunitinib Malate panthawi yake (masabata 50 mg / 4 patadutsa milungu iwiri) ndi omwe adalandira Sunitinib Malate ndi tchuthi pafupipafupi komanso mwachidule (ndandanda ina). Zinawoneka kuti kupulumuka konse, kupitilira kwaulere komanso kutsatira mankhwala osokoneza bongo kunali kwakukulu kwambiri mwa odwala omwe adalandira Sunitinib Malate panthawi ina. Odwala amakhalanso ndi kulekerera kwabwino komanso kuchepa kwa zochitika zoyipa zomwe nthawi zambiri zimayambitsa kusiya kwa chithandizo cha odwala khansa ya m'mitsempha ya m'mitsempha.

 

Suntinib Malate

 

Ndi Mankhwala Ena ati Omwe Angakhudze Sunitinib Malate?

Sunitinib Malate itha kubweretsa vuto lalikulu la mtima. Chiwopsezo chanu chikhoza kukhala chachikulu ngati mutagwiritsanso ntchito mankhwala ena opatsirana, mphumu, mavuto amtima, kuthamanga kwa magazi, kukhumudwa, matenda amisala, khansa, malungo, kapena HIV.

Nthawi zina sizowopsa kugwiritsa ntchito mankhwala ena nthawi imodzi. Mankhwala ena amatha kukhudza magazi omwe mumagwiritsa ntchito, omwe angapangitse mavuto ena kapena kuti mankhwalawo asakhale othandiza. Uzani dokotala wanu za mankhwala ena onse, makamaka: mankhwala a kufooka kwa mafupa.

Mndandanda uwu si wathunthu. Mankhwala ena angakhudze Sunitinib Malate, kuphatikizapo mankhwala ndi mankhwala owonjezera, mavitamini, ndi mankhwala azitsamba. Sizinthu zonse zomwe zingachitike pamankhwala pano.

 

FDA ivomereza Sunitinib Malate Monga Adjuvant Treatment Ya Renal Cell Carcinoma

Pa Novembala 16, 2017, Food and Drug Administration idavomereza Sunitinib Malate (Sunitinib Malate, Pfizer Inc.) yothandizira othandizira achikulire omwe ali pachiwopsezo chachikulu cha renal cell carcinoma kutsatira nephrectomy.

Kuvomerezeka kunakhazikitsidwa pamayeso apakatikati, apadziko lonse lapansi, akhungu awiri, olamulidwa ndi placebo (S-TRAC), mwa odwala 615 omwe ali pachiwopsezo chachikulu chobwereza RCC kutsatira nephrectomy. Odwala adasinthidwa 1: 1 kuti alandire 50 mg Sunitinib Malate kamodzi tsiku lililonse, masabata a 4 amalandila chithandizo chotsatira milungu iwiri, kapena placebo. Kupulumuka kwa matenda apakatikati kwa odwala omwe amatenga Sunitinib Malate anali zaka 2 (6.8% CI: 95, osafikiridwa) poyerekeza ndi zaka 5.8 (5.6% CI: 95, 3.8) kwa odwala omwe alandila placebo (HR = 6.6; 0.76% CI: 95 , 0.59; p = 0.98). Pa nthawi ya kusanthula kwa DFS, zambiri zopulumuka sizinali zokhwima.

Zotsatira zoyipa kwambiri (≥25%) ku Sunitinib Malate ndikutopa / asthenia, kutsegula m'mimba, mucositis / stomatitis, nseru, kuchepa kwa njala / anorexia, kusanza, kupweteka m'mimba, matenda amiyendo yamankhwala, matenda oopsa, kuthamanga kwa magazi, dysgeusia / kusintha kosintha , dyspepsia, ndi thrombocytopenia. Cholembedwacho chili ndi chenjezo lolembetsedwa kuti lidziwitse akatswiri azaumoyo komanso odwala za chiwopsezo cha hepatoxicity, chomwe chingayambitse chiwindi kapena kufa.

Mlingo woyenera wa Sunitinib Malate wothandizidwa ndi RCC ndi 50 mg pakamwa kamodzi patsiku, wopanda kapena kudya, masabata a 4 pachithandizo chotsatiridwa ndi milungu iwiri yopuma kwa masabata asanu ndi anayi asanu ndi limodzi.

 

Odziwika: Zambiri zodziwitsa zimapezeka pa:zandikirani.fda.gov  PDF 

 

Ndingagule Kuti Kuti Sunitinib Malate Paintaneti? 

Pali ogulitsa / opanga ambiri a Sunitinib Malate powder pamsika, kupeza wowona ndikofunikira kwambiri kwa anthu onse omwe amafunikira izi mwachangu. Tikaganiza zogula ufa wa Sunitinib Malate pamsika, tiyenera kuphunzira zambiri za izo, kudziwa momwe tingagwiritsire ntchito ndi magwiridwe antchito, zoopsa zilizonse tikatenga Sunitinib Malate powder…. Kuphatikiza apo, mtengo ndi mtundu wake ziyenera kukhala nkhawa zathu tisanagule.

Titasanthula madata ochokera kumsika, poyerekeza ambiri ogulitsa, AASraw imawoneka ngati njira yabwino kwa anthu omwe akufuna kugula zambiri Sunitinib Malate ufa, kupanga kwawo kumayang'aniridwa mosamalitsa pansi pa cGMP, mtunduwo ukhoza kutsatiridwa nthawi iliyonse ndipo atha kupereka malipoti onse oyesa mukamaitanitsa. Ponena za mtengo wa Sunitinib Malate powder / mtengo, ziyenera kukhala zomveka, m'maso mwanga. Chifukwa ndili ndi mitengo yambiri kuchokera kwa ogulitsa osiyanasiyana a Sunitinib Malate, poyerekeza ndi mtundu, ndikuganiza kuti aasraw sikhala chisankho choyipa.

AASraw ndiye katswiri wopanga Sunitinib Malate.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Reference

[1] Chakudya ndi Mankhwala Osokoneza Bongo. Sunitinib (Sutent) Kulongosola zambiri. 2015.

[2] CA Naranjo, U. Busto, ndi EM Sellers, "Njira yowerengera kuthekera kwa zovuta zamankhwala," Clinical Pharmacology and Therapeutics, vol. 30, ayi. 2, masamba 239-245, 1981.

[3] Z. Ansari ndi MK George, "thrombocytopenia wothandizidwa ndi mankhwala osokoneza bongo wachiwiri mpaka sunitinib mwa wodwala yemwe ali ndi metastatic renal cell carcinoma: lipoti lamilandu," Journal of Medical Case Reports, vol. 7, nkhani 54, 2013.

[4] K. Sakai, K. Komai, D. Yanase, ndi M. Yamada, "Plasma VEGF ngati chodziwitsa anthu za matenda ndi matenda a vasculitic neuropathy," Journal of Neurology, Neurosurgery and Psychiatry, vol. 76, ayi. 2, nkhani 296, 2005.

[5] European Medicines Agency. Sunitinib (SUTENT). Chidule cha Makhalidwe Azinthu. 2015.

[6] Pezani nkhaniyi pa intaneti Pajares B, Torres E, Trigo JM et al. Tyrosine kinase inhibitors komanso kulumikizana kwa mankhwala: kuwunikanso ndi malingaliro othandiza. Clin Kutanthauzira Oncol 2012; 14: 94-101.

[7] Teo YL, Ho HK, Chan A.Metabolism yokhudzana ndi kagayidwe kogwiritsa ntchito mankhwala osokoneza bongo ndi tyrosine kinase inhibitors: kumvetsetsa kwamakono, zovuta ndi malingaliro. Br J Clin Pharmacol 2015; 79: 241-253.

[8] Jamie Dlugosch (2009-03-13). "Kodi biologics ndi Sutent zipulumutsa Pfizer?". Wogulitsa Investment.

[9] BMJ 31-Jan-2009 "ZABWINO komanso zovuta za mankhwala a khansa" p271

[10] Blay JY, Reichardt P (Juni 2009). "Chotupa cham'mimba cham'mimba ku Europe: kuwunikanso malangizo othandizira mankhwala". Katswiri Rev Anticancer Ther. 9 (6): 831-8. onetsani: 10.1586 / era.09.34. MAFUNSO OTHANDIZA: PMID 19496720.

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