AASraw imapanga ufa wa Cannabidiol (CBD) ndi Hemp Mafuta Ofunika ambiri!

Anayankha

  1. Mankhwala Osankhidwa Ibrutinib (CAS: 936563-96-1)
  2. Njira Yogwirira Ntchito ya Ibrutinib
  3. Zomwe Ibrutinib Amagwiritsidwira Ntchito
  4. Ubwino / Zotsatira za Ibrutinib
  5. Kodi Tiyenera Kutenga Ibrutinib
  6. Zotsatira za Ibrutinib
  7. Kusunga kwa Ibrutinib

Mankhwala Otsatira Anayankha(CAS: 936563-96-1)

Mankhwala ambiri atsopano a lymphoma ndi mankhwala osokoneza bongo. Mankhwala oyenera cholinga chake ndikupha mtundu wa khungu lomwe lasandulika khansa kapena kuyimitsa zikwangwani zomwe zimapangitsa ma cell a khansa kukula kapena kugawikana. Mu lymphoma, mtundu wa khungu womwe umakhala khansa umatchedwa "lymphocyte" (mtundu wa khungu loyera lomwe limalimbana ndi matenda). Pali mitundu ingapo ya lymphocyte yomwe imatha kukhala khansa. Ibrutinib amalimbana ndi ma lymphocyte B (ma cell a B) motero amagwiritsidwa ntchito pochizira ma B-cell lymphomas.

Maselo amatumiza ndikulandila ma cell ena. Zina mwazizindikirozi zimapangitsa maselo kukhala amoyo ndikuwapangitsa kugawikana. Pali njira zambiri zosonyeza ndipo zizindikilo zimatumizidwa m'njira imodzi kapena zingapo. Ibrutinib ndi cell block blocker yomwe imayang'ana protein yotchedwa 'Bruton' s tyrosine kinase '(BTK). BTK ndi gawo la njira yomwe imathandizira ma cell a B kuti akhalebe amoyo ndikugawika. Kuletsa BTK kumatha kupanga maselo a B kufa kapena kuwaletsa kugawanika. Mankhwalawa atha kuletsa kufalikira kwa ma cell a khansa a B.

 

Anayankha Njira yogwira ntchito

Mwinilunga (936563-96-1) si mankhwala a chemotherapy koma ndi ena mwa mankhwala omwe amatchedwa "chithandizo chamankhwala." Chithandizo chomwe chikuyang'aniridwa ndi zotsatira za kafukufuku wazaka zambiri woperekedwa kuti amvetsetse kusiyana pakati pa maselo a khansa ndi maselo abwinobwino. Mpaka pano, chithandizo cha khansa chimangoyang'ana pakupha magawo omwe amagawa mwachangu chifukwa gawo limodzi la maselo am'magazi ndikuti amagawika mwachangu. Tsoka ilo, maselo athu abwinobwino amagawikanso mwachangu, ndikupangitsa zotsatirapo zingapo.

Thandizo lachidule ndilokulongosola zina mwa maselo a kansa. Asayansi amafufuza kusiyana komwe kumakhala ndi maselo a khansa komanso maselo ochibadwa. Chidziwitso chimenechi chikugwiritsidwa ntchito poyambitsa chithandizo chowopsya kuti chiwononge maselo a khansa popanda kuwononga maselo ochibadwa, motsogolere ku zotsatira zochepa. Njira iliyonse ya mankhwala opatsirana imagwira ntchito mosiyana koma zonse zimalepheretsa mphamvu ya khansa kukula, kugawa, kukonza ndi / kapena kuyankhulana ndi maselo ena.

Ibrutinib imaletsa kugwira ntchito kwa Bruton's tyrosine kinase (BTK). BTK ndi molekyulu yofunika kwambiri yodziwitsa ma B-cell receptor signature yomwe imagwira ntchito yofunika kwambiri pakupulumuka kwa maselo oyipa a B. Ibrutinib imatseka zikwangwani zomwe zimalimbikitsa ma cell a B kuti akule ndikugawana mosalamulirika. Kafukufuku akupitilizabe kuzindikira kuti ndi khansa iti yomwe imatha kuthandizidwa bwino ndi mankhwala omwe akuwatsata ndikuzindikiranso zina zomwe zingachitike pamitundu yambiri ya khansa.

Chidziwitso: Tikukulimbikitsani kuti mulankhule ndi akatswiri azaumoyo za matenda anu. Zomwe zili patsamba lino zimayenera kukhala zothandiza komanso zamaphunziro, koma sizilowa m'malo mwa upangiri wazachipatala.

AASraw ndiye katswiri wopanga Ibrutinib.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Zomwe Ibrutinib Amagwiritsidwira Ntchito

❶ Kuchiza anthu omwe ali ndi mantle cell lymphoma (MCL; khansa yomwe ikukula mwachangu yomwe imayamba m'maselo amthupi) omwe amalandira mankhwala amodzi.

❷ Kuchita ndi anthu aakulu lymphocytic khansa ya m'magazi (CLL; mtundu wa khansa womwe umayambira m'maselo oyera am'magazi) ndi ma lymphocytic lymphoma (SLL; mtundu wa khansa womwe umayamba makamaka m'ma lymph node).

❸ Kuchiza anthu omwe ali ndi Waldenstrom's macroglobulinemia (WM; khansa yomwe ikukula pang'onopang'ono yomwe imayamba m'maselo oyera m'magazi anu).

❹ Kuchiza anthu omwe ali ndi marginal zone lymphoma (MZL; khansa yomwe ikukula pang'onopang'ono yomwe imayamba ndi mtundu wamagazi oyera omwe nthawi zambiri amalimbana ndi matenda) omwe adalandira kale mtundu wina wa mankhwala a chemotherapy.

❺ Kuchiza anthu omwe ali ndi matenda amtengowo (cGVHD; vuto la kupatsirana kwa maselo am'magazi [HSCT; njira yomwe imalowetsa m'malo am'mafupa omwe ali ndi matenda ndi mafupa athanzi] yomwe imatha kuyamba kwakanthawi ndikukhazikitsanso ndikukhala kwakanthawi mutalandira chithandizo chimodzi kapena zingapo osapambana.

Ibrutinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

Anayankha

Anayankha ubwino/ Zotsatira

Ibrutinib imawerengedwa ndi akatswiri ambiri kuti ndi 'njira yopititsira patsogolo' mitundu ina ya lymphoma. Amapereka mayankho apamwamba poyerekeza ndi mankhwala ena amitundu yofanana ya lymphoma. Mayeso akulu omwe adapangitsa kuvomerezeka kwa ibrutinib afotokozedwa mwachidule pansipa.

 

(1) Zopindulitsa mu mantle cell lymphoma

Mantle cell lymphoma yomwe yabwereranso kapena sinayankhe kuchipatala choyamba ikhoza kukhala yovuta kuchiza. Komabe, kafukufuku wamkulu mderali adawonetsa kuti opitilira awiri mwa atatu mwa anthu 111 omwe amathandizidwa ndi ibrutinib adayankha kuchipatala (lymphoma yawo idachepa kapena kusowa).

Kafukufuku wachiwiri mwa anthu 280 adafanizira ibrutinib ndi mankhwala ena a khansa, temsirolimus, mwa anthu omwe abwereranso kapena obwezeretsa mantle cell lymphoma. Anthu amakhala pafupifupi miyezi 15 popanda lymphoma yawo ikuipiraipira akamathandizidwa ndi ibrutinib poyerekeza ndi pafupifupi miyezi 6 akachiritsidwa ndi temsirolimus.

 

(2) Ubwino mu matenda amitsempha yamagazi (CLL)

Mayankho okhalitsa awoneka mwa anthu omwe ali ndi CLL omwe amathandizidwa ndi ibrutinib. Poyesa kwakukulu komwe kumakhudza anthu 391 omwe abwerera m'mbuyo kapena okhazikika mu CLL, ibrutinib idafanizidwa ndi ofatumumab, yomwe imagwiritsidwa ntchito nthawi zambiri kwa anthu omwe ali ndi CLL omwe abwerera. Chaka chimodzi atayamba kulandira chithandizo, pafupifupi 66 mwa anthu 100 omwe amatenga ibrutinib anali ndi CLL yomwe idayang'aniridwa (izi zimadziwika kuti 'kupitilira kopanda kupitirira') poyerekeza ndi anthu pafupifupi 6 mwa 100 omwe amathandizidwa ndi ofatumumab.

Pakafukufuku wachiwiri wokhudza anthu 269 omwe anali asanalandire chithandizo chilichonse cha CLL yawo, ibrutinib anafanizidwa ndi chemotherapy mankhwala a chlorambucil. Pambuyo pa chithandizo cha zaka 1.5, pafupifupi anthu 90 mwa 100 omwe amatenga ibrutinib anali ndi CLL yomwe idalamuliridwa poyerekeza ndi anthu pafupifupi 52 mwa anthu 100 omwe amathandizidwa ndi chlorambucil.

Kuphatikiza ibrutinib ku bendamustine ndi rituximab kwa anthu omwe abwereranso kapena osinthira CLL kunathandizanso pa kafukufuku wokhudza anthu 578. Kuopsa kwakukula kwa CLL kunachepetsedwa potenga ibrutinib m'malo mwa placebo (dummy treatment).

 

(3) Ubwino ku Waldenström' s macroglobulinaemia (WM)

Kuwonjezeka kwakukulu kwawonekeranso mwa anthu omwe ali ndi WM - pafupifupi 9 mwa anthu 10 omwe ali ndi WM adayankhidwa mankhwala a ibrutinib pamlandu mwa anthu 63. Mlanduwu udachita bwino kwambiri ku WM chifukwa ndi njira yachilendo ya lymphoma motero ndizovuta kupeza anthu okwanira kuti athe kutenga nawo mbali pazoyeserera zamankhwala. Mlanduwu udapangitsa kuti ibrutinib ivomereze WM ku Europe.

 

Kodi Tiyenera Kutenga Bwanji Anayankha 

Mudzapatsidwa ibrutinib ngati mapiritsi. Itha kuperekedwa limodzi ndi mankhwala ena omwe mukufuna. Mukamalandira chithandizo nthawi zambiri mumawona dotolo wa cance¬r, namwino wa khansa kapena namwino waluso, komanso katswiri wazamankhwala. Izi ndi zomwe timatanthauza tikamanena za dokotala, namwino kapena wamankhwala pazomwezi.

Asanafike kapena patsiku la chithandizo, namwino kapena munthu wophunzitsidwa kumwa magazi (phlebotomist) amatenga magazi kuchokera kwa inu. Izi ndikuti muwone ngati maselo anu amagazi ali bwino kuti mulandire chithandizo.

Mudzaonana ndi dokotala kapena namwino musanalandire chithandizo. Akufunsani momwe mumamvera. Zotsatira za magazi anu zikakhala bwino, wamankhwala amakonzekeretsani chithandizo chanu. Namwino wanu adzakuwuzani nthawi yomwe mankhwala anu angakhale okonzeka.

Namwino kapena wamankhwala amakupatsani mapiritsi a ibrutinib kuti mupite nawo kunyumba. Nthawi zonse muziwatenga ndendende momwe amafotokozera. Izi ndizofunikira kuwonetsetsa kuti zikugwirirani ntchito moyenera. Mutha kupatsidwa mapiritsi okhala ndi mphamvu zosiyanasiyana. Nthawi zambiri mumasunga kutenga ibrutinib tsiku lililonse bola azisamalira khansa. Namwino wanu kapena wamankhwala amathanso kukupatsirani mankhwala olimbana ndi matenda ndi mankhwala ena oti mupite nawo kunyumba. Tengani mapiritsi anu onse ndendende momwe akufotokozereni.

AASraw ndiye katswiri wopanga Ibrutinib.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Chikumbutso Chofunda pa Kudzisamalira

♦ Mukamamwa ibrutinib, imwani madzi okwanira malita awiri kapena atatu maola 24 aliwonse, pokhapokha mutalangizidwa.

♦ Sambani m'manja nthawi zambiri ndipo mukalandira mlingo uliwonse wa ibrutinib.

♦ Mutha kukhala pachiwopsezo chotenga matenda kotero yesetsani kupewa khamu kapena anthu omwe ali ndi chimfine, ndipo nenani malungo kapena zizindikiro zilizonse zadzidzidzi kwa omwe akukuthandizani.

♦ Kuthandiza kuchiza / kupewa zilonda mkamwa mukamamwa ibrutinib, gwiritsani ntchito mswachi wofewa, ndikutsuka katatu patsiku ndi supuni 1 ya soda yophatikiza ndi ma ola 8 amadzi.

♦ Gwiritsani ntchito lezala lamagetsi ndi mswachi wofewa kuti muchepetse magazi.

♦ Pewani masewera olumikizana kapena zochitika zomwe zitha kuvulaza.

♦ Kuti muchepetse mseru, imwani mankhwala ochepetsa mseru monga adanenera dokotala, ndipo idyani zakudya zazing'ono, pafupipafupi mukamwa ibrutinib.

♦ Idyani zakudya zomwe zingathandize kuchepetsa kutsekula m'mimba-onani Kuthetsa mavuto oyipa - Kutsekula m'mimba

♦ Tsatirani ndondomeko ya mankhwala oletsa kutsegula m'mimba monga mwalembedwera ndi azaumoyo.

Pewani kuwonekera padzuwa. Valani dzuwa la SPF 15 (kapena kupitilira apo) ndi zovala zoteteza. Ibrutinib itha kukupangitsani kuti muzimva bwino dzuwa ndipo mutha kupsa ndi dzuwa mosavuta.

General Mwambiri, kumwa zakumwa zoledzeretsa kuyenera kuchepetsedwa kapena kupewa kwathunthu mukamamwa ibrutinib. Muyenera kukambirana izi ndi dokotala wanu.

♦ Muzipuma mokwanira.

♦ Khalani ndi zakudya zabwino mukamamwa mankhwala a ibrutinib.

♦ Ngati mukumva zizindikiro kapena zotsatirapo mukamamwa ndi ibrutinib, onetsetsani kuti mukukambirana ndi gulu lanu lazachipatala. Amatha kukupatsirani mankhwala ndi / kapena kupereka malingaliro ena othandiza kuthana ndi mavutowa.

 

Anayankha Spano Ezimayambitsa

Pezani chithandizo chamankhwala chodzidzimutsa ngati muli ndi zizindikiro zotsutsa: ming†™ oma; kupuma kovuta; Kutupa kwa nkhope, milomo, lilime, kapena mmero.

 

Lekani kugwiritsa ntchito ibrutinib ndipo itanani dokotala nthawi yomweyo ngati muli:

♦ Zizindikiro za matenda-malungo, kuzizira, kufooka, zilonda mkamwa, kutsokomola ndi ntchofu, kupuma movutikira;

♦ Zizindikiro zakutuluka magazi mkati mwathupi- chizungulire, kufooka, kusokonezeka, mavuto pakulankhula, kupweteka kwa mutu kwa nthawi yayitali, ndowe zakuda kapena zamagazi, mkodzo wapinki kapena wabulauni, kapena kutsokomola magazi kapena masanzi omwe amawoneka ngati malo a khofi;

Di Kutsekula m'mimba koopsa;

Pain Kupweteka pachifuwa, kugunda kwa mtima kapena kukuwuluka pachifuwa, kumverera ngati kutha;

Headache Mutu wopweteka kwambiri, kusawona bwino, kupindika m'khosi kapena makutu;

Kuvulaza kosavuta, magazi osazolowereka, zofiirira kapena zofiira pansi pa khungu lanu;

Skin Khungu loyera, manja ozizira ndi mapazi;

Problems Mavuto a impso-kukodza pang'ono kapena ayi, kutupa pamapazi anu kapena akakolo; kapena

♦ Zizindikiro zakutha kwa chotupa-kusokonezeka, kufooka, kukokana kwa minofu, kusanza, kusanza, kugunda kwa mtima kapena kuchepa kwa mtima, kuchepa pokodza, kumva kulira m'manja ndi m'mapazi kapena mkamwa.

 

Zotsatira zowonjezereka zingaphatikizepo:

♦ Kutsekula m'mimba, nseru;

Ever Kutentha thupi, kutsokomola, kupuma movutikira;

♦ Matuza kapena zilonda mkamwa mwanu;

Eling Kumva kutopa;

Ru Kuluma, ziphuphu; kapena

Pain Kupweteka kwa minofu, kupweteka kwa mafupa.

Izi siziri mndandanda wathunthu wa zotsatirapo ndipo ena akhoza kuchitika. Dandauzani dokotala wanu kuti akuthandizeni zachipatala zokhudzana ndi zotsatira. Mutha kuyankha FDA ku 1-800-FDA-1088.

AASraw ndiye katswiri wopanga Ibrutinib.

Chonde dinani apa kuti mumve zambiri: Ochezera ife

 

Anayankha Smazunzo

Sungani Ibrutinib mu chidebe chomwe chidalowa, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi osati kubafa.

Ibrutinib yosafunikira iyenera kutayidwa m'njira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangathe kuzidya. Komabe, simuyenera kutsuka Ibrutinib iyi mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani Kutaya Kwabwino kwa FDA kwa

Ndikofunika kuti mankhwala onse asamaoneke komanso kuti ana azikhala ndi zida zambiri (monga mapiritsi apakati pa mlungu ndi madontho, maso, mavitamini, ndi inhalers) sagonjetsedwa ndi ana ndipo akhoza kuwatsegula mosavuta. Pofuna kuteteza ana aang'ono ku poizoni, nthawi zonse mutseka makapu a chitetezo ndipo nthawi yomweyo perekani mankhwalawa pamalo otetezeka - omwe ali pamwamba ndi kutali ndi osawona ndi kufika.

 

Reference

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[5] Woyach JA, Ruppert AS, Guinn D, ndi al. BTKC481S-yolimbana ndi ibrutinib mu matenda a khansa ya m'magazi. J Clin Oncol. (Adasankhidwa) 2017; 35 (13): 1437-1443.

[6] Winqvist M, Asklid A, Andersson PO, ndi al. Zotsatira zenizeni za ibrutinib mwa odwala omwe ali ndi khansa ya m'magazi yomwe yabwereranso kapena yowonongeka: deta kuchokera kwa odwala 95 otsatizana omwe amathandizidwa mwachidwi. Kafukufuku wochokera ku Sweden Chronic Lymphocytic Leukemia Group. Haematologica. 2016; 101 (12): 1573-1580. (Adasankhidwa)

[7] Jones JA, Hillmen P, Coutre S, ndi al. Kugwiritsa ntchito ma anticoagulants ndi antiplatelet mwa odwala omwe ali ndi lemphocytic leukemia omwe amathandizidwa ndi ibrutinib wothandizira m'modzi. Br J Haematol. 2017; 178 (2): 286-291. (Adasankhidwa)

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[9] Rigg RA, Aslan JE, Healy LD, ndi al. Kuwongolera pakamwa kwa Bruton's tyrosine kinase inhibitors kumapangitsa kuti ntchito ya GPVI yolumikizidwa ndi ma platelet igwire ntchito. Ndine J Physiol Cell Physiol. 2016; 310 (5): C373-C380.

[10] Wang ML, Rule S, Martin P, et al. Kulimbana ndi BTK ndi ibrutinib munthawi yobwezeretsanso kapena yowonongeka-cell lymphoma. N Engl J Med. 2013; 369 (6): 507-516.

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[12] Lampson BL, Yu L, Glynn RJ, ndi al. Ventricular arrhythmias ndi kufa kwadzidzidzi kwa odwala omwe amatenga ibrutinib. Magazi. 2017; 129 (18): 2581-2584.

[13] Tedeschi A, Frustaci AM, Mazzucchelli M, Cairoli R, Montillo M. Kodi HBV prophylaxis imafunika panthawi ya chithandizo cha CLL ndi ibrutinib? Leuk Lymphoma. 2017; 58 (12): 2966-2968. (Adasankhidwa)

[14] Dzuwa C, Tian X, Lee YS, et al. Kukhazikitsanso pang'ono chitetezo chamthupi komanso matenda ochepa mwa odwala omwe ali ndi khansa ya m'magazi yothandizidwa ndi ibrutinib. Magazi. 2015; 126 (19): 2213-2219.

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[16] Ahn IE, Jerussi T, Farooqui M, Tian X, Wiestner A, Gea-Banacloche J. Atypical Pneumocystis jirovecii chibayo mwa odwala omwe sanalandire chithandizo omwe ali ndi CLL pa wothandizira mmodzi ibrutinib. Magazi. 2016; 128 (15): 1940-1943.

[17] Vitale C, Ahn IE, Sivina M, ndi al. Autoimmune cytopenias mwa odwala omwe ali ndi lemphocytic leukemia yothandizidwa ndi ibrutinib. Haematologica. 2016; 101 (6): e254-e258.

[18] Mlomo GY, Pan X, Kamble S, et al. Kuwonongeka kwakukulu kwa magazi pakati pa odwala omwe si a valvular atrial fibrillation oyambitsidwa apixaban, dabigatran, rivaroxaban powder kapena warfarin: kafukufuku wowonera "dziko lenileni" ku United States. Int J Zipatala. 2016; 70 (9): 752-763.

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