Tykerb (231277-92-2) -Wakupha mkaka wa m'mawere AASraw agule Tykerb
AASraw imapanga ufa wa Cannabidiol (CBD) ndi Hemp Mafuta Ofunika ambiri!

 

Vuto la phala la Lapatinib

 

 


 

I.Lapatinib ufa Anthu oyambirira:

 

Name: Lapatinib ufa
CAS: 231277-92-2
Maselo chilinganizo: C29H26ClFN4O4S
Kulemera kwa Maselo: 581.05
Melt Point: 136-140 ° C
Kusungirako nyengo: Firiji
mtundu; Yoyera kapena kuchotsa nyemba yakuyera ya Crystalline

 


 

1.Tykerb otchulidwa phulusa.

 

dzina Tykerb
Cas 231277-92-2
Molecular Formula C29H26CIFN4O4S
Kulemera kwa maselo 581.05
mtundu Yoyera kapena kuchotsa nyemba yakuyera ya Crystalline
Dzina lina lapatini

 


 

2.Chiani Tykerb?

 

Mayina amalonda a Tykerb ndi Tyverb ndi mankhwala okhudzana ndi khansa ya m'mawere ndi zina zotupa. Ndi awiri a tyrosine kinase inhibitor omwe amasokoneza njira ya HER2 / neu ndi epidermal kukula factor receptor (EGFR) njira. Amagwiritsidwa ntchito pothandizana pamodzi kwa khansa ya m'mawere ya HER2. Amagwiritsidwa ntchito pochiza odwala ali ndi kansa yapakhungu kapena yamatenda omwe amatulutsa overexpress HER2 (ErbB2) Makamaka US idalemba Tyker ndipo makamaka ku Europe ndi Russia amatcha Tyverb.Mu Januware 2010, Tykerb adalandira chilolezo chofulumira chakuchiza azimayi a postmenopausal omwe ali ndi khansa ya m'mawere yolandila metastatic Lapatinib imalepheretsa njira yolandirira polumikizira thumba la ATP ya gawo la EGFR / HER2 protein kinase, yodziyimira pawokha-phosphorylation ndikuyambitsanso makinawo, Tykerb (lapatinib) ndi mankhwala a khansa omwe amagwiritsidwa ntchito pamodzi ndi mankhwala ena omwe amatchedwa capecitabine (Xeloda) kuti adziwe mtundu wina wa khansa yapakati ya m'mawere yomwe yafalikira kumbali zina za thupi, ndipo nthawi zambiri amaperekedwa pambuyo pa mankhwala ena a khansa popanda kuyesedwa bwino.

 

 


 

3.Kodi ili bwanji Tykerb ntchito?

 

Chithandizo cha khansa cha m'mawere chimayika makamaka kupha mwapang'onopang'ono maselo chifukwa chimodzi mwa ziwalo za khansa ya m'mawere ndi chakuti amagawana mofulumira.Achidule cha mankhwalawa ndikulongosola zochitika zina za khansa ya m'mawere maselo.Alipo mitundu yosiyanasiyana ya mankhwala ochiritsidwa, omwe amatchulidwa muzigawo zitatu. Zina zothandizira zamankhwala zimaganizira zofunikira za mkati komanso ntchito ya khansa ya m'mawere. Njira zochiritsirazo zimagwiritsa ntchito mamolekyu ang'onoang'ono omwe angalowe mu selo ndi kusokoneza ntchito ya maselo, kuwapangitsa kufa. Pali mitundu yambiri ya mankhwala opatsirana omwe amayang'ana mkati mwa maselo. Zina zogwiritsidwa ntchito ndi zothandizira zakulandila zomwe zili kunja kwa selo. Mankhwala omwe amalimbana ndi mapiritsi amadziwikanso amadzimadzi a monoclonal. Antiangiogenesis inhibitors amayang'ana mitsempha ya magazi yomwe imapereka mpweya ku maselo, ndipo pamapeto pake imachititsa maselo kukhala ndi njala.Pertuzumab ndi antioclonal antibody yomwe imayang'ana pamwamba pa maselo a epidermal growth factor receptor 2 protein (HER2) pa selo ya khansa, yotsutsana ndi HER2 yomwe imayambitsa khansa ya m'mawere ya m'mawere. Pertuzumab imamangirira kumalo ena a mapuloteni a HER2 kusiyana ndi trastuzumab kuti pamene pertuzumab ili pamodzi ndi trastuzumab, kutsekedwa kwathunthu kwa HER2 kuonekera kumachitika mkati mwa khungu la khansa ya bere ya HER2, HER2 receptors amagwiritsa ntchito mapuloteni, otchedwa kinases, kuti ayambitse selo likukula ndikugawa molakwika. Kinase amayang'anira kuchuluka kwa mphamvu ya maselo kuti ikule ndikuchuluka. Maselo a khansa ya m'mawere omwe amachititsa kuti HER2 ikhale ndi zochita zambiri, kotero maselo a khansa amakula kwambiri, mofulumira kwambiri.Tykerb imagwira ntchito polepheretsa maukwati a HER2 mkati mwa selo, kuchepetsa kuchuluka kwa maselo a khansa ya m'mawere akuyenera kukula ndi kuchulukitsa . Mwa kuchepetsa kuchuluka kwa mphamvu, Tykerb ikhoza kuchepetsa kapena kuletsa kukula kwa khansa ya m'mawere.

 

 


 

4.Kodi Tykerb Ikugwirani Ntchito?

 

Mayesero anayi angagwiritsidwe ntchito kuti aone ngati kansa ndi HER2-positive ndipo ngati idzayankha Tykerb:

 

  • IHC (ImmunoHistoChemistry)

IHC ndiyeso lomwe limagwiritsidwa ntchito kwambiri kuti liwone ngati chotupa chili ndi mapuloteni ambiri a HER2 pamwamba pamaselo a khansa. Kuyesedwa kwa IHC kumapereka 0 mpaka 3+ yomwe imawonetsa kuchuluka kwa mapuloteni a HER2 m'matumbo. Ngati chotupacho chimapeza 0 mpaka 1+, chimatchedwa "HER2 negative." Ngati itapeza 2+ kapena 3+, amatchedwa "HER2 positive." Amayi omwe ali ndi zotsatira zabwino za IHC amakonda kuyankha Tykerb. Mankhwalawa sagwiritsidwa ntchito moyenera pa zotupa ndi IHC zilembo za 0 kapena 1 +.

 

  • Nsomba (Fluorescence In Situation Hybridization)

Mayeso a FISH amafufuzira mtundu wa HER2 wosalongosoka. Mayesowa ndi olondola kwambiri, koma osachepera, omwe angapeze ngati chotupa cha m'mawere chikhoza kuyankha kwa Tykerb ..

Ndi mayeso a FISH, mumalandira mphambu ya “positive” kapena “negative” (zipatala zina zimati kuyeza kolakwika ndi “zero”). Ngati khansara ili ndi FISH positive, itha kuyankha Tykerb.

 

Mayeso a SpoT-Light HER2 CISH amayang'ana majini a HER2 mumtundu wa khansa ya m'mawere. Kuyesa kwa SpoT-Light kumagwiritsa ntchito banga lomwe limapangitsa majini a HER2 / neu kusintha mtundu. Ndi mayeso a SPoT-Light, mumapeza zigoli za "zabwino" kapena "zoyipa." Ngati khansara ili ndi SPoT-Light, itha kuyankha bwino kwa Tykerb.

 

  • Lembani HER2 Dual ISH (In Situation Hybridization)

Mauthenga a HER2 Dual ISH amagwiritsira ntchito banga lapadera lomwe limapangitsa kuti HER2 mapuloteni asinthe mtundu. Tsamba limagwiritsidwa ntchito ku zitsanzo za khansa ya m'mawere ndi kuyang'ana pansi pa microscope. Chiyesochi chimapereka zotsatira zenizeni kuposa HC HER HER.Tsiku lodziwitsa mayeso a HER2 Dual ISH, mumapeza mpikisano wa "HER2 zabwino" kapena "HER2".

 


 

5.Kodi kugwiritsidwa ntchito kwa mankhwala a Tykerb ndi kotani?

 

Tykerb imakonzedwa ndi michere ya chiwindi CYP3A4. Mankhwala omwe amaletsa kapena kuyambitsa CYP3A4 atha kukhudza kuchuluka kwa Tykerb mthupi. Ma inhibitor amachulukitsa kuchuluka kwa magazi a Tykerb ndipo ma inducers amachepetsa magazi ake. Kusintha kwa mlingo wa Tykerb kuyenera kuganiziridwa kwa odwala omwe alandila mphamvu ya CYP3A4 inhibitors kapena inducers. Otsatirawa si mndandanda wathunthu wa zoletsa ndi ma inducers.

 


 

6.Tykerb Mbali Zotsatira

 

Common zotsatira zoyipazi wa Tykerb ndi awa:

kunyoza, kusanza, kupwetekedwa m'mimba, zilonda zam'kamwa, kuthamanga, khungu louma, ululu kapena kuphulika pamanja a manja anu kapena mapazi anu, tsitsi lanu, mavuto anu ndi zokopa zanu, ndikuphatikizira kugona. Pamene Tykerb akuperekedwa ndi Xeloda chemotherapy , mukhoza kutenga mankhwala okhudza mankhwala a chemotherapy. Makamaka, Xeloda amagwirizanitsidwa ndi matenda a ubongo, kapena kufiira ndi kumangiriza m'manja ndi mapazi. Pamene Tykerb amaperekedwa ndi Femara, inunso mukhoza kukhala ndi zotsatira za Femara. Zotsatira zoyipa za Femara ndi fupa zopepuka komanso kupweteka kwa mafupa. Tkerker sawoneka kuti amachititsa mavuto a mtima ndi mapapu okhudzana ndi Herceptin. Ngati mutenga pakati kapena kuganiza kuti mutha kutenga pakati, muuzeni dokotala wanu. Sichidziwika ngati mankhwalawa akudutsa mkaka wa m'mawere. Chifukwa cha kuyamwa kwa khanda, kuyamwa pamene mukugwiritsa ntchito mankhwalawa sikuvomerezedwa.

 


 

7.Wodi ndi machenjezo ndi zotani za Tykerb?

 

  • Tykerb ingakhudze momwe mtima umapopera magazi. Onetsetsani kachigawo kakang'ono kotsekedwa ka ventricular (LVEF) musanayambe Tykerb ndikupitiriza kuyang'anitsitsa pakapita mankhwala.
  • Tykerb kawirikawiri imayambitsa matenda osagwidwa ndi chiwindi. Onetsetsani chiwindi kugwira ntchito musanayambe kuchipatala komanso masabata onse a 4-6 panthawi ya mankhwala.
  • Tykerb ingachititse kutsekula m'mimba. Ngati kutsekula m'mimba kumachitika, sungani ndi anti-diarrheal mawonekedwe ndi mmalo mwa madzi.
  • Tykerb ingayambitse mavuto aakulu a m'mapapu. Kuleka Tykerb ngati zizindikiro za izi zikuchitika.
  • Tykerb ingayambitse vuto lalikulu la khungu. Zimasiya Tykerb ngati izi zikuchitika.

 

 


 

8.Kodi mlingo wa Tykerb ndi wotani?

 

  • Tykerb imaperekedwa ngati mapiritsi a 250 mg. Mapiritsi asanu amatengedwa kamodzi tsiku lililonse tsiku lililonse m'mimba yopanda kanthu kwa masiku 21 pakuzungulira kwa masiku 21. Osaphwanya kapena kutafuna mapiritsi. Sungani kutentha ndikuyika chidebe chatsekedwa mwamphamvu. T Tykerb imaperekedwa ndi Xeloda (capecitabine) 2000mg / m2 / tsiku lomwe limaperekedwa pakamwa pamiyeso iwiri yogawanika, maola 2 kupatula masiku 12 oyamba a aliyense Zotsatira za masiku a 21. Capecitabine iyenera kutengedwa ndi chakudya kapena maminiti 30 pambuyo pa chakudya.
  • Tengani mankhwala awa monga momwe adanenera. Tsatirani malangizo anu pamakalata anu mosamala.
  • Mlingo umene dokotala wanu amalimbikitsa ukhoza kukhala wotsatira:
  • chikhalidwe chomwe chikuchitiridwa
  • matenda ena omwe muli nawo
  • mankhwala ena omwe mukuwatenga
  • momwe mumayankhira mankhwalawa
  • kulemera kwanu, kutalika kwa msinkhu wanu, msinkhu wanu, chikhalidwe chanu

 

Mlingo woyenera wa lapatinib wa khansa yapakati kapena yamatenda am'mimba ndi 1,250 mg (mapiritsi 5) operekedwa pakamwa kamodzi tsiku lililonse pa Masiku 1-21. Mlingo woyenera wa lapatinib wa khansa ya m'mawere yolandila (HER2-positive) khansa ya m'mawere ndi 1,500 mg (Mapiritsi 6) operekedwa pakamwa kamodzi tsiku lililonse mosalekeza kuphatikiza ndi letrozole.

 


 

9.Kodi mtengo wa Tykerb?

 

Avereji Zamtengo Wapatali: $ 30.10 pa 250 mg piritsi

Tsiku la 21 Supply (1 ulendo): $ 3,160.50

 


 

10.Kodi kugwiritsidwa ntchito kwa mankhwala a Tykerb ndi kotani?

 

Tykerb imakonzedwa ndi michere ya chiwindi CYP3A4. Mankhwala omwe amaletsa kapena kukopa CYP3A4 angakhudze anthu ambiri a Tykerb mu thupi. Zizindikiro zimayambitsa magazi a Tykerb ndi inducers amachepetsa m'magazi ake. Kusintha kwazitsulo kwa Tykerb kuyenera kuganiziridwa kwa odwala omwe amalandira mphamvu CYP3A4 inhibitors kapena inducers. Zotsatilazi sizomwe muli mndandandanda wa ziwalo zowonongeka.

Mavitamini: ketoconazole, clarithromycin, atazanavir, nefazodone, nelfinavir (Viracept), telithromycin, ndi voriconazole.

Inducers: dexamethasone, phenytoin, carbamazepine, rifampin, phenobarbital, ndi St John's wort.

 


 

11.Kodi ndikapitirira?

 

ngati inu sunganis lapatinib, itanani dokotala wanu kapena malo oletsa poyizoni, kapena pitani kuchipatala chadzidzidzi chapafupi pomwepo. Tengani mapiritsi a lapatinib nanu ngati kuli kotheka.

 


 

12.Kodi ndingapeze zambiri zambiri?

 

Kumbukirani, sungani mankhwalawa ndi mankhwala ena onse, musagwiritse ntchito mankhwala anu ndi ena, ndipo mugwiritseni ntchito mankhwalawa pokhapokha ngati mwalemba.
Kuyesetsa konse kwachitika kuti zitsimikizidwe kuti zomwe zimaperekedwa ndi AASraw zaposachedwa, ndikumaliza, koma palibe chitsimikizo chomwe chimapangidwa. Zambiri zamankhwala zomwe zili pano zitha kukhala zovuta nthawi. Zambiri za AASraw zidalembedwa kuti zizigwiritsidwa ntchito ndi akatswiri azaumoyo komanso ogula ku United States chifukwa chake AASraw sikutanthauza kuti kugwiritsa ntchito kunja kwa United States kuli koyenera, pokhapokha atanenedwa mwanjira ina. AASrawChidziwitso cha mankhwala sichikugwirizana ndi mankhwala, kuwunika odwala kapena kuwalimbikitsa. Chidziwitso cha mankhwala a AASraw ndichinthu chodziwitsira chomwe chimapangidwa kuti chithandizire akatswiri azachipatala posamalira odwala awo ndi / kapena kuthandiza ogula akuwona ntchitoyi ngati chowonjezera, osati cholowa m'malo mwa ukadaulo, luso, chidziwitso ndi kuweruza kwa akatswiri azaumoyo. Kusapezeka kwa chenjezo la mankhwala osakaniza kapena mankhwala osagwiritsidwa ntchito mwanjira iliyonse sikuyenera kutanthauzidwa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito kapena oyenera wodwala aliyense. AASraw satenga udindo uliwonse pazinthu zilizonse zothandizira zaumoyo zomwe zimaperekedwa mothandizidwa ndi chidziwitsoAASraw imapereka. Zomwe zili pano sizongotengera momwe angagwiritsire ntchito, mayendedwe, zodzitetezera, machenjezo, kuyanjana ndi mankhwala osokoneza bongo, zovuta zina, kapena zovuta zina. Ngati muli ndi mafunso okhudzana ndi mankhwala omwe mukumwa, funsani dokotala, namwino kapena wamankhwala.

 


 

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