Zowonjezera Minofu Yotetezeka Kwambiri: Urolithin A (UA) Powder AASraw
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Chimodzi mwa zolinga zazikulu za omanga thupi ndi othamanga ndikuwonjezera minofu yowonda ndikuwongolera kamvekedwe, komanso mphamvu, ya minofu. Zingakhale zovuta kukwaniritsa izi pochita masewera olimbitsa thupi kapena maphunziro okha. Kukonzekera mokhazikika kwa chakudya, kudya zakudya zofunikira kwambiri, komanso kugwiritsa ntchito zakudya zina zolimbitsa thupi zisanakwane ndi kulimbitsa thupi kumafunika kuti pakhale kukula kwa minofu mu nthawi yoikidwiratu.

Pali njira zambiri zosinthira kukula kwa minofu yanu ndikuwona kusintha kwakukulu m'thupi lanu, chofunikira kwambiri chomwe ndikudya mapuloteni okwanira. Kudya mapuloteni ndi chakudya chilichonse kungapindulitse kukula kwa minofu yanu, chifukwa ma amino acid ochokera ku mapuloteniwa amathandiza kukonza kuwonongeka kwa minofu ndikubwezeretsanso mapuloteni osungira mu minofu, pambuyo pochita masewera olimbitsa thupi kwambiri. Zakudya zama carb ziyenera kupewedwa nthawi zambiri, kupatula pambuyo pochita masewera olimbitsa thupi pamene kukula kwa minofu ndiko cholinga.

Njira ina yofulumira yolimbikitsira kukula kwa minofu ndi kugwiritsa ntchito steroids. Nthawi zambiri amakhala ndi mbiri yoyipa monga mitundu ina ya steroid yoletsedwa kuti igwiritsidwe ntchito ndi omanga thupi kapena wothamanga ndi maulamuliro ogwirizana. Komabe, pali mitundu ina yambiri yomwe ili yotetezeka komanso yovomerezeka kuti igwiritsidwe ntchito, yomwe yatsimikiziridwa kuti ndi yopindulitsa kupyolera mu maphunziro angapo a sayansi.

Steroids angagwiritsidwe ntchito pamutu, kapena kutengedwa ngati piritsi kapena jekeseni, mwachindunji mu minofu. Cholinga cha ma steroids sichimangowonjezera kukula kwa minofu, motero kumapangitsa kuti minofu ikule kwambiri komanso kuwonjezera mphamvu za minofu. Omanga thupi omwe amagwiritsa ntchito steroids amafotokoza kusintha kwa mphamvu ndi kupirira mu masewera olimbitsa thupi, zomwe ndithudi zimawonjezera mokomera ma steroids.

Urolithin A (UA) Ufa - 01

Poyerekeza ndi Steroid, Kodi Ubwino Wa Urolithin A (UA) Ndi Chiyani?

Ngati kusalidwa kozungulira ma steroid kukukulirakulira ndipo mukuyang'ana njira ina, ndiye Urolithin A yowonjezera kungakhale koyenera kuyang'ana. Urolithin A ufa ndi mphamvu yamphamvu komanso yotetezeka ya minofu, yomwe phindu lake lathandizidwa ndi umboni weniweni wa sayansi. Ubwino wa minyewa yamtunduwu yakhala ikubwerezedwa ndikuyesedwa m'maphunziro osiyanasiyana osiyanasiyana, ndipo aliyense wathandizira zopindulitsa zongopeka. 

Ma anabolic steroids omwe othamanga amagwiritsira ntchito amatha kusintha kukula kwa minofu kwambiri koma zotsatira za mankhwalawa, monga kuchepa kwa testicular chifukwa cha testicular atrophy ndi infertility, zimaposa phindu la mankhwalawa. Ichi ndichifukwa chake ndikofunikira kuyang'ana njira zina, ndipo Urolithin A ali ndi potency yofanana kapena yowonjezereka, poyerekeza, yomwe imapangitsa kukula kwa minofu. Komabe, zotsatira za Urolithin A sizili pafupi kukhala zovuta monga zotsatira za steroids.

Urolithin A. ndiwowonjezera otetezeka komanso ogwira mtima omwe ali ndi anti-kukalamba, kagayidwe kachakudya, neuroprotective, ndi anti-kunenepa kwambiri. Malinga ndi maphunziro omwe adachitika kuti awone ubwino wa zowonjezera, ndizotetezeka kuti zigwiritsidwe ntchito ndi anthu. Komanso, palibe zomwe zanenedwapo za poizoni kapena zoyipa zomwe zanenedwa, mpaka pano. Kugwiritsa ntchito mankhwala oyenera mu mlingo woyenera kungathandize kuchepetsa chiopsezo cha zotsatira zilizonse zomwe zingatheke kwambiri.

Urolithin A, kuyambira pomwe idapezeka m'zaka za m'ma 2000, idaphunziridwa mozama chifukwa cha zopindulitsa zake monga kulimbikitsa minofu ndi kuthekera kowonjezera kupirira. Komabe, palinso maubwino ena ochepa omwe adapezeka chifukwa cha kafukufukuyu, ndipo atchulidwa pansipa:

  • Kuwongolera zovuta za metabolic

Poyesa kuthekera kwa Urolithin A supplement kuti apititse patsogolo kupirira kwa okalamba, ofufuza adapeza kuti metabolite idachepetsa kwambiri kuchuluka kwa ceramides ndi acylcarnitine m'thupi. Izi nthawi zambiri zimakhudzidwa ndi zovuta za metabolic zomwe zimayang'ana mitochondria. Chifukwa chake zidaganiziridwa kuti Urolithin A itha kuthandiza kuthana ndi vuto la metabolic la mitochondrial. 

  • Zotsatira zoyipa

Ngakhale kuti phindu la Urolithin A lowonjezera silili losangalatsa monga momwe lingathe kulimbikitsa kukula kwa minofu, ndilofunikanso. Malinga ndi kafukufuku wopangidwa pazitsanzo za nyama, zidapezeka kuti kugwiritsa ntchito metabolite kumawongolera zizindikiro za Alzheimer's, ngakhale kuti kafukufuku wowonjezera akufunika asanayambe kugwiritsidwa ntchito ngati njira yochiritsira.

  • Zotsutsana ndi kunenepa kwambiri

Urolithin A anaphunziridwanso chifukwa cha ubwino wake wa kagayidwe kachakudya pamene ubwino umodzi unapezeka mwangozi panthawi ya kafukufuku yemwe anali kuchitidwa kuti asanthule kugwiritsa ntchito Urolithin A kuti apititse patsogolo kupirira kwa minofu pakati pa okalamba. 

Zitsanzo za nyama pazakudya zamafuta ambiri kapena HFD zidaphunziridwa pomwe zidapatsidwa Urolithin A chowonjezera. Urolithin A mu mbewa zonenepazi zidapangitsa kuyanika kwa minofu yoyera ya adipose ndiyeno, Urolithin A imalimbikitsa thermogenesis yamafuta a bulauni, kusungunula mafutawo. Urolithin A sikuti amangosungunula mafuta koma adapezekanso kuti ateteze kunenepa pakati pa mbewa zomwe zidadyetsedwa HFD. Izi za metabolic komanso zotsutsana ndi kunenepa kwambiri za Urolithin A ufa zitha kutsegula dziko latsopano la mwayi ndikugwiritsa ntchito metabolite.

Kodi Urolithin A (UA) ndi chiyani?

Urolithin A ndi mankhwala omwe amapangidwa kuchokera ku ellagitannins ndi microbiota m'matumbo. Urolithins ndi mankhwala onunkhira a polycyclic omwe ndi metabolites opangidwa kuchokera kuzinthu zoyambira monga ellagic acid ndi ellagitannins, zomwe zimapezeka mu zipatso zachilengedwe monga makangaza.

Peel ya makangaza imakhala yochuluka Urolithin B pomwe Urolithin A alibe gwero lenileni lazakudya. M'malo mwake, amapangidwa ndi kutembenuka kwa ma tannins omwe amapezeka mu zipatso ndi zomera za m'matumbo. Mapangidwe a zakudya za ellagitannins akutchulidwa mu tebulo ili m'munsimu. Zakudya izi zimakhala ngati magwero osalunjika a Urolithin A, pamaso pa matumbo athanzi a microbiota omwe amatha kutembenuza.

Zakudya Ellagic Acid
zipatso 
Mabulosi akuda 150
Mabulosi akuda akuda 90
Achimwene 70
Mawonekedwe a mtambo 315.1
makangaza 269.9
Ma rasipiberi 270
Ananyamuka m'chiuno 109.6
Froberries 77.6
Kupanikizana Strawberry 24.5
Raspberries wachikasu 1900
Mtedza (mg / g)
mtedza 33
Walnuts 59
Zakumwa (mg / L)
Madzi a makangaza 811.1
Mowa wamphesa 31-55
Vinyo wofiira wazaka zambiri 33
Whisky 1.2
Mbewu (mg / g)
Mabulosi akuda akuda 6.7
Ma rasipiberi ofiira 8.7
Achimwene 30
wamango 1.2

Kodi Urolithin-A Imagwira Ntchito Motani Pakukulitsa Minofu?

Urolithin A watenga malo a steroids pamsika popeza ndi otetezeka komanso olimbikitsa minofu. Otsatsa a Urolithin A amalimbikitsa kugwiritsa ntchito chowonjezera ichi chifukwa cha ubwino wambiri wa mankhwalawa, omwe chofunika kwambiri ndi kukula kwa minofu. Mphamvu ya minofu, kukula, ndi kupirira zimadalira kwambiri ntchito ya mitochondrial m'maselo. Mitochondria ndi mphamvu ya selo, ndipo ali ndi udindo wopanga ATP, yomwe ndi ndalama zamphamvu za thupi. 

-Kulimbitsa Minofu kwa Okalamba

Munthu akamakalamba, mphamvu ya minofu, kukula kwake, ndi kupirira zimachepa kwambiri. Izi zitha kuimbidwa mlandu chifukwa cha kuchepa kwa magwiridwe antchito a mitochondria komanso kuchuluka kwa mitochondria yolephera. Kuchepetsa kwa mitophagy uku kumagwira ntchito yofunika kwambiri polepheretsa okalamba kuchita ntchito za tsiku ndi tsiku ndi ntchito. Njira yothetsera vutoli yapezeka kuti ndi ufa wa Urolithin A. 

Panali phunziro lina lomwe linachitidwa ndi cholinga chodziwira zotsatira za Urolithin A pa mphamvu ya minofu ndi kupirira kwa okalamba, omwe amawona kuchepa kwa ntchito ya mitochondrial ndi zaka. 

Malinga ndi ofufuza omwe achita mayeso azachipatala, panali lingaliro la kulephera kwa mitophagy pakati pa omwe adachita nawo kafukufukuyu, zomwe zikuwonetsa kuchotsedwa kwa mitochondria yosokonekera komanso kusintha kwa thanzi la mitochondrial. Poyerekeza ndi gulu lomwe lidalandira placebo, otenga nawo mbali adapereka Urolithin A yowonjezera lipoti kusintha kwakukulu kwa chipiriro ndi mphamvu ya minofu m'miyendo ndi manja. Panali kuchepa kwa kutopa komanso kusintha kwakukulu pakutha kugwira ntchito za tsiku ndi tsiku. 

Ofufuza adanenanso kuti Urolithin A yowonjezera ikhoza kukhala njira ina yowonjezera mphamvu za minofu ndi mphamvu pakati pa okalamba omwe sangathe kuchita masewera olimbitsa thupi chifukwa cha thanzi kapena maganizo. Malinga ndi Center for Disease Control and Prevention kapena CDC, kuchita masewera olimbitsa thupi tsiku ndi tsiku kungathandize kuthana ndi vuto la kuyenda, kugwa, ndi zovuta zina zakuyenda kwa okalamba. Komabe, ngati izi sizingatheke, kutenga Urolithin A zowonjezera kungapangitse mitophagy kukhala yokhazikika, motero, kukhala ndi zotsatira zofanana ndi zolimbitsa thupi. 

-Kusamalira Duchenne Muscular Dystrophy

Komabe, ndi matenda osokonekera aminofu monga Duchenne Muscular Dystrophy kapena DMD, mitochondrial yomwe ili m'maselo imakhala yolakwika ndipo mitochondria yomwe ilipo sigwira ntchito bwino. Komanso, mu DMD, mitophagy imachepetsedwa kwambiri, yomwe ndi njira yomwe matupi athu amachotsa mitochondria yosagwira ntchito ndikubwezeretsanso zomwe zili mkati kuti zikwaniritse zofuna zamphamvu za thupi. 

Chimodzi mwazofukufuku omwe adachitika kuti aphunzire zotsatira za Urolithin Ufa pa kukula kwa minofu umayang'ana kwambiri momwe wakale ali nawo pa mitophagy. Ofufuza adapeza kuti kuphatikizika ndi Urolithin A kumathandizira kwambiri mitophagy, kuwabwezeretsa kunthawi zonse kwa odwala omwe ali ndi vuto la muscular dystrophy. Zotsatirazi zidawonedwa pazitsanzo za nyama komanso nkhani za anthu, zomwe zikuwonetsa kuti Urolithin A itha kugwiritsidwa ntchito bwino pakuwongolera zizindikiro za muscular dystrophies. Kuphatikiza apo, ofufuza adalemba chiwonjezeko cha 40 peresenti ya kupulumuka kwa nyama zomwe zidapatsidwa Urolithin A chowonjezera poyerekeza ndi omwe sanalandire chowonjezera. Mphamvu yogwira ndi mphamvu yothamanga idakwera ndi 31 peresenti ndi 45 peresenti, motero, mumitundu iyi yanyama. 

Ubwino wina wofunikira wa Urolithin A supplementation womwe udawonedwa panthawi ya kafukufukuyu ndikuti umachepetsa fibrosis kapena mabala amtima ndi diaphragm ya mbewa ndi DMD. Ichi ndi vuto lalikulu la DMD lomwe lingathe kuwongoleredwa Urolithin A ufa.

Urolithin A (UA) Ufa -03

Komwe Mungagule Ufa Wabwino Kwambiri wa Urolithin A (UA) Pa intaneti?

Pali othandizira angapo a Urolithin A pa intaneti omwe ali ndi masamba awo odzipereka omwe angasankhidwe kuti agule metabolite. Ogulitsa ogulitsa amalola ogwiritsa ntchito kugula ufa wa Urolithin A pa intaneti, ndikutumiza kwanthawi yake. Ogulitsa awa amangogwiritsa ntchito ufa, osati zowonjezera zomwe zimapangidwa ndi metabolite iyi. Zowonjezera za Urolithin A zitha kugulidwa mwachindunji kuchokera ku mtundu womwe mwasankha kapena ku Amazon.

Musanagule katundu wambiri kapena zowonjezera, tikulimbikitsidwa kuyang'ana ndemanga zazinthu kuti muwonetsetse kuti choyambirira, champhamvu, komanso chothandiza chikugulidwa. Pali ma dupe ambiri pamsika ndipo nthawi zina, zomwe zimagulidwa zitha kuipitsidwa ndi zosakaniza zina kapena poizoni. Ndibwino kuti mufufuze bwino za chitetezo ndi chiyero cha ufa wa Urolithin A musanayambe kuyitanitsa ngakhale pang'ono.

Urolithin A yowonjezera imapezeka m'njira zosiyanasiyana monga makapisozi a ufa kapena gel ofewa. Kuyitanitsa mwachindunji kuchokera ku Urolithin. Wothandizira akhoza kukuthandizani kuti musankhe njira yoyenera yowonjezeramo nokha. Fomu ikatsimikiziridwa, ndikofunikira kusankha mlingo woyenera nokha. Ndikofunika kukumbukira kuti ufa wa Urolithin A uyenera kutengedwa kamodzi patsiku, mlingo uliwonse uli pafupi ndi 500mg. 

Pali magwero angapo a chakudya cha Urolithin A koma sikokwanira kudya zakudya zomwe zili ndi zoyamba za Urolithin A. Payenera kukhala mitundu iwiri ya bakiteriya yomwe imapezeka m'matumbo amtundu wa ellagitannins kuti iwonongeke ku Urolithin A. mitundu ndi, Gordonibacter pamelaeae (DSM 19378T) ndi Gordonibacter urolithinfaciens (DSM 27213T).

Ngati mitundu iyi sipezeka m'matumbo a m'matumbo, ndiye kuti munthu wokhudzidwayo sapanga Urolithin A m'thupi. Anthu otere amayenera kutenga zowonjezera kuti athandizire kusowa kwa kutembenuka kwa Urolithin m'thupi.

Kodi Tingaone Zotsatira Zotani Pambuyo pa Urolithin-A Powder?

Urolithin A yatsimikiziridwa, kupyolera mu kafukufuku wa sayansi ndi maphunziro, kukhala ndi zotsatira zotsutsana ndi ukalamba pa mphamvu ya minofu, kukula, ndi kupirira. Zopindulitsa zonse zimathandizidwa ndi umboni wa sayansi ndipo nthawi yochepa yomwe maphunzirowa adachitidwa inali miyezi inayi. Maphunzirowa adatenga miyezi inayi kapena kuposerapo, ndipo ofufuza ambiri adanena kuti zowonjezera za Urolithin A zimafunikira miyezi inayi kuti apange mitophagy ndi phindu la metabolic.

Reference:

[1]Guada M, Ganugula R, Vadhanam M, Ravi Kumar MNV. Urolithin A Imachepetsa Nephrotoxicity Yopangidwa ndi Cisplatin Poletsa Kutupa kwa Impso ndi Apoptosis mu Chitsanzo Choyesera Makoswe. J Pharmacol Exp Ther. 2017;363(1):58-65. doi:10.1124/jpet.117.242420.
[2] "FDA GRAS chidziwitso GRN No. 791: urolithin A". US Food and Drug Administration. 20 December 2018. Yabwezedwanso 25 August 2020.
[3]Landete JM (2011). "Ellagitannins, ellagic acid ndi metabolites yawo yochokera: kuwunikanso za gwero, metabolism, ntchito ndi thanzi". Food Research International. 44 (5): 1150–1160. doi:10.1016/j.foodres.2011.04.027.
[4] Johanningsmeier SD, Harris GK (2011-02-28). "Pomegranate ngati chakudya chogwira ntchito komanso gwero lazakudya". Ndemanga Yapachaka ya Sayansi Yazakudya ndi Zamakono. 2 (1): 181–201. doi:10.1146/annurev-chakudya-030810-153709. PMID 22129380.
[5] Han QA, Yan C, Wang L, Li G, Xu Y, Xia X. Urolithin A amalepheretsa ox-LDL-induced endothelial dysfunction pang'onopang'ono mwa modulating microRNA-27 ndi ERK/PPAR-γ njira. Mol Nutr Food Res. 2016;60(9):1933-1943. doi:10.1002/mnfr.201500827.

AASraw ndi katswiri wopanga Urolithin A (UA) ufa womwe uli ndi labu yodziyimira pawokha komanso fakitale yayikulu monga chithandizo, zonse zopanga zizichitika motsogozedwa ndi CGMP ndikuwongolera kachitidwe kabwino. Dongosolo lothandizira limakhala lokhazikika, malonda onse ogulitsa ndi ogulitsa ndi ovomerezeka.Mwalandiridwa kuti mudziwe zambiri za AASraw!

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